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3C3U

Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid

Summary for 3C3U
Entry DOI10.2210/pdb3c3u/pdb
DescriptorAldo-keto reductase family 1 member C1, ZINC ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordsaldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, akr1c1, cytoplasm, nadp, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q04828
Total number of polymer chains1
Total formula weight37855.16
Authors
Dhagat, U.,El-Kabbani, O. (deposition date: 2008-01-28, release date: 2008-08-26, Last modification date: 2023-11-01)
Primary citationDhagat, U.,Endo, S.,Sumii, R.,Hara, A.,El-Kabbani, O.
Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid
J.Med.Chem., 51:4844-4848, 2008
Cited by
PubMed: 18620380
DOI: 10.1021/jm8003575
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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