3C3U
Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid
Summary for 3C3U
Entry DOI | 10.2210/pdb3c3u/pdb |
Descriptor | Aldo-keto reductase family 1 member C1, ZINC ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | aldo-keto reductase, 20 alpha hydroxysteroid dehydrogenase, akr1c1, cytoplasm, nadp, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q04828 |
Total number of polymer chains | 1 |
Total formula weight | 37855.16 |
Authors | Dhagat, U.,El-Kabbani, O. (deposition date: 2008-01-28, release date: 2008-08-26, Last modification date: 2023-11-01) |
Primary citation | Dhagat, U.,Endo, S.,Sumii, R.,Hara, A.,El-Kabbani, O. Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid J.Med.Chem., 51:4844-4848, 2008 Cited by PubMed: 18620380DOI: 10.1021/jm8003575 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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