3CV6

The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.

Summary for 3CV6

DescriptorAldo-keto reductase family 1 member C21, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, ... (5 entities in total)
Functional Keywordsaldo-keto reductase, hydroxysteroid dehydrogenase, ternary complex, hexestrol, lipid metabolism, nadp, oxidoreductase, phosphoprotein, steroid metabolism
Biological sourceMus musculus (Mouse)
Total number of polymer chains2
Total molecular weight76427.62
Authors
Dhagat, U.,El-Kabbani, O. (deposition date: 2008-04-17, release date: 2009-03-03, Last modification date: 2019-11-13)
Primary citation
Dhagat, U.,Endo, S.,Mamiya, H.,Hara, A.,El-Kabbani, O.
Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.
Acta Crystallogr.,Sect.D, 65:257-265, 2009
PubMed: 19237748 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444908044028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25111 0.2% 1.7%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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