2PZN

The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant

Summary for 2PZN

• Entry DOI: 10.2210/pdb2pzn/pdb
• Related: 1US0
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID, ... (4 entities in total)
• Functional Keywords: aldose reductase, atomic resolution, ternary complex, inhibitor binding, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37006.48

Authors

Ruiz, F.,Hazemann, I.,Darmanin, C.,Mitschler, A.,Van Zandt, M.,Joachimiak, A.,El-Kabbani, O.,Podjarny, A. (deposition date: 2007-05-18, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Ruiz, F.,Hazemann, I.,Darmanin, C.,Mitschler, A.,Van Zandt, M.,Joachimiak, A.,El-Kabbani, O.,Podjarny, A.; The Crystallographic Structure of Alr2-Idd393 Complex Confirms Leu300 as a Specificity Determinant; To be Published,

Experimental method

X-RAY DIFFRACTION (1 Å)