2R24
Human Aldose Reductase structure
Summary for 2R24
Entry DOI | 10.2210/pdb2r24/pdb |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (4 entities in total) |
Functional Keywords | beta/alpha-8 tim barrel, cataract, nadp, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37057.98 |
Authors | Blakeley, M.P.,Ruiz, F.,Cachau, R.,Hazemann, I.,Meilleur, F.,Mitschler, A.,Ginell, S.,Afonine, P.,Ventura, O.N.,Cousido-Siah, A.,Haertlein, M.,Joachimiak, A.,Myles, D.,Podjarny, A. (deposition date: 2007-08-24, release date: 2008-12-23, Last modification date: 2024-02-21) |
Primary citation | Blakeley, M.P.,Ruiz, F.,Cachau, R.,Hazemann, I.,Meilleur, F.,Mitschler, A.,Ginell, S.,Afonine, P.,Ventura, O.N.,Cousido-Siah, A.,Haertlein, M.,Joachimiak, A.,Myles, D.,Podjarny, A. Quantum model of catalysis based on mobile proton revealed by subatomic X-Ray and neutron diffraction studies of h-Aldose Reductase Proc.Natl.Acad.Sci.USA, 105:1844-1848, 2008 Cited by PubMed: 18250329DOI: 10.1073/pnas.0711659105 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.194 Å) X-RAY DIFFRACTION (1.752 Å) |
Structure validation
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