3DN5
Aldose Reductase in complex with novel biarylic inhibitor
Summary for 3DN5
| Entry DOI | 10.2210/pdb3dn5/pdb |
| Related | 2ikg |
| Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid, ... (4 entities in total) |
| Functional Keywords | tim barrel, nadph binding site, acetylation, cataract, cytoplasm, nadp, oxidoreductase, phosphoprotein, polymorphism |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm: P15121 |
| Total number of polymer chains | 1 |
| Total formula weight | 36919.04 |
| Authors | Steuber, H.,Klebe, G. (deposition date: 2008-07-01, release date: 2009-04-07, Last modification date: 2023-11-01) |
| Primary citation | Eisenmann, M.,Steuber, H.,Zentgraf, M.,Altenkamper, M.,Ortmann, R.,Perruchon, J.,Klebe, G.,Schlitzer, M. Structure-Based Optimization of Aldose Reductase Inhibitors Originating from Virtual Screening Chemmedchem, 4:809-819, 2009 Cited by PubMed: 19301313DOI: 10.1002/cmdc.200800410 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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