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3CAV

Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-pregnan-3,20-dione

Summary for 3CAV
Entry DOI10.2210/pdb3cav/pdb
Related3CAQ 3CAS
Descriptor3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5BETA)-PREGNANE-3,20-DIONE, ... (6 entities in total)
Functional Keywords5b-reductase, 5beta-reductase, 5b-red, akr1d1, akr, aldo-keto reductase, nadp, androstenedione. nadph, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P51857
Total number of polymer chains2
Total formula weight77442.17
Authors
Faucher, F.,Cantin, L.,Breton, R. (deposition date: 2008-02-20, release date: 2008-07-29, Last modification date: 2011-07-13)
Primary citationFaucher, F.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R.
The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Biochemistry, 47:8261-8270, 2008
Cited by
PubMed: 18624455
DOI: 10.1021/bi800572s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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