3CV7

Crystal structure of porcine aldehyde reductase ternary complex

Summary for 3CV7

Related2AO0
DescriptorAlcohol dehydrogenase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordstim barrel, aldo-keto reductase, ternary complex, acetylation, nadp, oxidoreductase
Biological sourceSus scrofa (pig)
Total number of polymer chains1
Total molecular weight37961.62
Authors
Carbone, V.,El-Kabbani, O. (deposition date: 2008-04-18, release date: 2008-10-28, Last modification date: 2011-07-13)
Primary citation
Carbone, V.,Chung, R.,Endo, S.,Hara, A.,El-Kabbani, O.
Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity
Arch.Biochem.Biophys., 479:82-87, 2008
PubMed: 18782556 (PDB entries with the same primary citation)
DOI: 10.1016/j.abb.2008.08.014
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.412 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24570.6%5.1%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution