3DOP

Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-dihydrotestosterone, Resolution 2.00A

Summary for 3DOP

• Entry DOI: 10.2210/pdb3dop/pdb
• Related: 3CMF
• Descriptor: 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-beta-DIHYDROTESTOSTERONE, ... (4 entities in total)
• Functional Keywords: product, bile acid catabolism, cytoplasm, disease mutation, intrahepatic cholestasis, lipid metabolism, nadp, oxidoreductase, steroid metabolism
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P51857
• Total number of polymer chains: 2
• Total formula weight: 80975.77

Authors

Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. (deposition date: 2008-07-05, release date: 2008-10-28, Last modification date: 2023-11-01)

• Primary citation: Di Costanzo, L.,Drury, J.E.,Christianson, D.W.,Penning, T.M.; Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1); Mol.Cell.Endocrinol., 301:191-198, 2009; PubMed: 18848863; DOI: 10.1016/j.mce.2008.09.013

Experimental method

X-RAY DIFFRACTION (2 Å)