PDB: 1205 件ウェブページステータス検索Chemie searchBIRD

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8PWN	Structure of A2A adenosine receptor A2AR-StaR2-bRIL, solved at wavelength 2.75 A 分子名称: Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, OLEIC ACID, ... 著者 El Omari, K, Duman, R, Mykhaylyk, V, Orr, C, Romano, M, Moraes, I, Wagner, A. 登録日 2023-07-20 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Experimental phasing opportunities for macromolecular crystallography at very long wavelengths. Commun Chem, 6, 2023
7YFC	Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex 分子名称: CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Im, D, Iwata, S, Asada, H. 登録日 2022-07-08 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
7YFD	Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex 分子名称: 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, CHOLESTEROL, Engineered G-alpha-q, ... 著者 Im, D, Iwata, S, Asada, H. 登録日 2022-07-08 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
8HPT	Structure of C5a-pep bound mouse C5aR1 in complex with Go 分子名称: Antibody fragment ScFv16, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
8I9A	Structure of EP54-C3aR-Gq complex 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, EP54 ligand, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-06 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8I95	Structure of EP54-C3aR-Go complex 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, EP54 ligand, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-06 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8IA2	Structure of C5a bound human C5aR1 in complex with Go (Composite map) 分子名称: Antibody fragment - ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-07 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8I9S	Structure of Apo-C3aR-Go complex (Titan) 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-07 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8I9L	Structure of C3a-C3aR-Go complex (Composite map) 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-07 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8I97	Structure of Apo-C3aR-Go complex (Glacios) 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-02-06 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8HQC	Structure of a GPCR-G protein in complex with a natural peptide agonist 分子名称: Antibody fragment, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
8JZZ	Structure of human C5a-desArg bound human C5aR1 in complex with Go 分子名称: Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-07-06 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8J6D	Structure of EP141-C3aR-Go complex 分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, EP141 peptide agonist, ... 著者 Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. 登録日 2023-04-25 公開日 2023-10-18 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
8KH5	Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8E0G	Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ... 著者 Munro, T.A. 登録日 2022-08-09 公開日 2023-10-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
8HQN	Activation mechanism of GPR132 by 9(S)-HODE 分子名称: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HVI	Activation mechanism of GPR132 by compound NOX-6-7 分子名称: 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HQM	Activation mechanism of GPR132 by NPGLY 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8H2G	Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Park, J.H, Ishimoto, N, Park, S.Y. 登録日 2022-10-06 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis for hydroxy-carboxylic acid receptor 2 activation and allosteric mechanism To Be Published
8KGK	Cryo-EM structure of the GPR61-Gs complex 分子名称: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S. 登録日 2023-08-19 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8KH4	Cryo-EM structure of the GPR161-Gs complex 分子名称: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8HQE	Cryo-EM structure of the apo-GPR132-Gi 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8SAI	Cryo-EM structure of GPR34-Gi complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Yong, X.H, Zhao, C, Yan, W, Shao, Z.H. 登録日 2023-04-01 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
8TB0	Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16 分子名称: GPR61 fused to dominant negative G alpha S/I N18 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Lees, J.A, Dias, J.M, Han, S. 登録日 2023-06-28 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14, 2023
8TB7	Cryo-EM Structure of GPR61- 分子名称: 6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide, Fab hinge-binding nanobody, Fab24 BAK5 heavy chain, ... 著者 Lees, J.A, Dias, J.M, Han, S. 登録日 2023-06-28 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14, 2023

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