Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 348 件

7BPH
DownloadVisualize
BU of 7bph by Molmil
Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GN13
分子名称: CHLORIDE ION, GLYCEROL, GN13, ...
著者Hu, Q, Dai, S, Shokat, K.M.
登録日2020-03-22
公開日2021-03-31
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides.
Cell, 2022
6AU6
DownloadVisualize
BU of 6au6 by Molmil
Crystal structure of GDP-bound human GNAS R201C mutant
分子名称: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者Hu, Q, Shokat, K.M.
登録日2017-08-30
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Disease-Causing Mutations in the G Protein G alpha s Subvert the Roles of GDP and GTP.
Cell, 173, 2018
8F0K
DownloadVisualize
BU of 8f0k by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L.
登録日2022-11-03
公開日2023-08-02
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
7MBX
DownloadVisualize
BU of 7mbx by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gs complex
分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
著者Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
登録日2021-04-01
公開日2021-05-26
最終更新日2021-07-14
実験手法ELECTRON MICROSCOPY (1.95 Å)
主引用文献Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
7E5E
DownloadVisualize
BU of 7e5e by Molmil
Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20
分子名称: CHLORIDE ION, GD20, GUANOSINE-5'-DIPHOSPHATE, ...
著者Hu, Q, Dai, S, Shokat, K.M.
登録日2021-02-18
公開日2022-03-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides.
Cell, 185, 2022
8F2B
DownloadVisualize
BU of 8f2b by Molmil
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
登録日2022-11-07
公開日2023-08-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F0J
DownloadVisualize
BU of 8f0j by Molmil
Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
登録日2022-11-03
公開日2023-08-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
6X19
DownloadVisualize
BU of 6x19 by Molmil
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
分子名称: 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Zhang, X, Danev, R.
登録日2020-05-18
公開日2020-09-09
最終更新日2020-11-18
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X18
DownloadVisualize
BU of 6x18 by Molmil
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor
分子名称: Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Zhang, X, Danev, R.
登録日2020-05-18
公開日2020-09-09
最終更新日2020-11-18
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
7RTB
DownloadVisualize
BU of 7rtb by Molmil
Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)
分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Johnson, R.M, Danev, R, Sexton, P.M, Wootten, D.
登録日2021-08-12
公開日2021-10-06
実験手法ELECTRON MICROSCOPY (2.14 Å)
主引用文献Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.
Biochem.Biophys.Res.Commun., 578, 2021
8F2A
DownloadVisualize
BU of 8f2a by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D.
登録日2022-11-07
公開日2023-08-02
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
7TYF
DownloadVisualize
BU of 7tyf by Molmil
Human Amylin1 Receptor in complex with Gs and rat amylin peptide
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-13
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
8E3X
DownloadVisualize
BU of 8e3x by Molmil
Cryo-EM structure of the PAC1R-PACAP27-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Piper, S.J, Danev, R, Sexton, P, Wootten, D.
登録日2022-08-17
公開日2022-11-23
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Understanding VPAC receptor family peptide binding and selectivity.
Nat Commun, 13, 2022
8E3Y
DownloadVisualize
BU of 8e3y by Molmil
Cryo-EM structure of the VPAC1R-PACAP27-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Piper, S.J, Danev, R, Sexton, P, Wootten, D.
登録日2022-08-17
公開日2022-11-23
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Understanding VPAC receptor family peptide binding and selectivity.
Nat Commun, 13, 2022
6UVA
DownloadVisualize
BU of 6uva by Molmil
CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide
分子名称: Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
登録日2019-11-01
公開日2020-04-01
最終更新日2020-04-29
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6WZG
DownloadVisualize
BU of 6wzg by Molmil
Human secretin receptor Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Piper, S.J, Belousoff, M.J, Danev, R.
登録日2020-05-13
公開日2020-08-12
最終更新日2020-09-02
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
7WCM
DownloadVisualize
BU of 7wcm by Molmil
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
分子名称: 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Qiao, A.N, Wu, S, Ye, S.
登録日2021-12-20
公開日2022-12-21
最終更新日2022-12-28
実験手法ELECTRON MICROSCOPY (2.33 Å)
主引用文献Activation and signaling mechanism revealed by GPR119-G s complex structures.
Nat Commun, 13, 2022
7XKF
DownloadVisualize
BU of 7xkf by Molmil
Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex at lower state
分子名称: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
登録日2022-04-19
公開日2022-08-10
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
7XKD
DownloadVisualize
BU of 7xkd by Molmil
Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex
分子名称: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
登録日2022-04-19
公開日2022-08-10
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
9AUC
DownloadVisualize
BU of 9auc by Molmil
Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
著者Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
登録日2024-02-28
公開日2024-04-24
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
6UUS
DownloadVisualize
BU of 6uus by Molmil
CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide
分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
登録日2019-10-31
公開日2020-04-01
最終更新日2020-04-29
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
7TZF
DownloadVisualize
BU of 7tzf by Molmil
Human Amylin3 Receptor in complex with Gs and rat amylin peptide
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-15
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7UTZ
DownloadVisualize
BU of 7utz by Molmil
Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
分子名称: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ...
著者Faust, B, Cheng, Y, Manglik, A.
登録日2022-04-28
公開日2022-08-03
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7S1M
DownloadVisualize
BU of 7s1m by Molmil
Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1)
分子名称: Ex4-D-Ala, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cary, B.P, Gellman, S.H.
登録日2021-09-02
公開日2022-01-05
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献Structural and functional diversity among agonist-bound states of the GLP-1 receptor.
Nat.Chem.Biol., 18, 2022
8X79
DownloadVisualize
BU of 8x79 by Molmil
MRE-269 bound Prostacyclin Receptor G protein complex
分子名称: 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C.
登録日2023-11-23
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024

222036

件を2024-07-03に公開中

PDB statisticsPDBj update infoContact PDBjnumon