8F2B

Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45

Summary for 8F2B

• Entry DOI: 10.2210/pdb8f2b/pdb
• EMDB information: 28812
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, PALMITIC ACID, (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, ... (13 entities in total)
• Functional Keywords: gpcr, amylin receptor, dual amylin and calcitonin receptor agonists, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 191394.26

Authors

Cao, J.,Sexton, P.M.,Wootten, D.L.,Belousoff, M.J. (deposition date: 2022-11-07, release date: 2023-08-02, Last modification date: 2024-03-13)

• Primary citation: Cao, J.,Belousoff, M.J.,Gerrard, E.,Danev, R.,Fletcher, M.M.,Dal Maso, E.,Schreuder, H.,Lorenz, K.,Evers, A.,Tiwari, G.,Besenius, M.,Li, Z.,Johnson, R.M.,Wootten, D.,Sexton, P.M.; Structural insight into selectivity of amylin and calcitonin receptor agonists.; Nat.Chem.Biol., 20:162-169, 2024; PubMed: 37537379; DOI: 10.1038/s41589-023-01393-4

Experimental method

ELECTRON MICROSCOPY (2 Å)