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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8F2B

Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer39445683.41UniProt (P63092)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-stimulating G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35038534.11UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(N)		nanobody 35polymer13815140.71Lama glama (Llama)
5E
(E)		Receptor activity-modifying protein 3polymer14916896.71UniProt (O60896)
Pfam (PF04901)		Homo sapiens (human)Calcitonin-receptor-like receptor activity-modifying protein 3,CRLR activity-modifying protein 3
6F
(P)		pramlintide analogue San45polymer383968.51Pfam (PF00214)
UniProt (by SIFTS) (P10997)		Homo sapiens
7G
(R)		Calcitonin receptorpolymer50158469.61UniProt (P30988)
Pfam (PF02793)
Pfam (PF00002)		Homo sapiens (human)CT-R
8H
(P)		N-hexadecanoyl-L-glutamic acidnon-polymer385.51Chemie (D6M)
PubChem (23390005)
PubChem (161955)
PubChem (3649795)
9I, J, K
(R)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.23Chemie (NAG)
10L, M, N, O, P...
(R)		PALMITIC ACIDnon-polymer256.48Chemie (PLM)
11T
(R)		(2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphatenon-polymer766.11Chemie (P42)
PubChem (49867470)
12U, V
(R)		CHOLESTEROL HEMISUCCINATEnon-polymer486.72Chemie (Y01)
PubChem (16219150)
PubChem (22210610)
PubChem (65082)
PubChem (363416)
PubChem (45489984)
PubChem (500055)
PubChem (60078761)
PubChem (57163942)
PubChem (73440805)
PubChem (89891013)
PubChem (13301926)
PubChem (13301927)
PubChem (99567469)
PubChem (99567468)
PubChem (124427194)
PubChem (124897021)
PubChem (124897020)
PubChem (10005657)
PubChem (130340716)
PubChem (11969853)
PubChem (124301053)
PubChem (124302591)
PubChem (124303794)
PubChem (124421343)
PubChem (124427195)
PubChem (137392566)
PubChem (137496323)
PubChem (124914595)
PubChem (124914596)
PubChem (131705526)
PubChem (155804219)
PubChem (137332121)
PubChem (137496357)
PubChem (146157332)
PubChem (169132514)
PubChem (154929912)
PubChem (155199678)
PubChem (156327905)
PubChem (156426247)
PubChem (156516588)
PubChem (166979870)
PubChem (167024614)
PubChem (169132513)
PubChem (170117245)
PubChem (172400028)
13W, X, Y
(A, P, R)		waterwater18.031Chemie (HOH)
Sequence modifications
A: 1 - 394 (UniProt: P63092)
PDBExternal DatabaseDetails
Asn 54Ser 54engineered mutation
Ala 226Gly 226engineered mutation
Ala 268Glu 268engineered mutation
Lys 271Asn 271engineered mutation
Asp 274Lys 274engineered mutation
Lys 280Arg 280engineered mutation
Asp 284Thr 284engineered mutation
Thr 285Ile 285engineered mutation
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
E: 24 - 148 (UniProt: O60896)
PDBExternal DatabaseDetails
Met 0-expression tag
Lys 1-expression tag
Thr 2-expression tag
Ile 3-expression tag
Ile 4-expression tag
Ala 5-expression tag
Leu 6-expression tag
Ser 7-expression tag
Tyr 8-expression tag
Ile 9-expression tag
Phe 10-expression tag
Cys 11-expression tag
Leu 12-expression tag
Val 13-expression tag
Phe 14-expression tag
Ala 15-expression tag
Asp 16-expression tag
Tyr 17-expression tag
Lys 18-expression tag
Asp 19-expression tag
Asp 20-expression tag
Asp 21-expression tag
Asp 22-expression tag
Lys 23-expression tag
R: 25 - 474 (UniProt: P30988)
PDBExternal DatabaseDetails
Met -7-expression tag
Lys -6-expression tag
Thr -5-expression tag
Ile -4-expression tag
Ile -3-expression tag
Ala -2-expression tag
Leu -1-expression tag
Ser 0-expression tag
Tyr 1-expression tag
Ile 2-expression tag
Phe 3-expression tag
Cys 4-expression tag
Leu 5-expression tag
Val 6-expression tag
Phe 7-expression tag
Ala 8-expression tag
Asp 9-expression tag
Tyr 10-expression tag
Lys 11-expression tag
Asp 12-expression tag
Asp 13-expression tag
Asp 14-expression tag
Asp 15-expression tag
Leu 16-expression tag
Glu 17-expression tag
Val 18-expression tag
Leu 19-expression tag
Phe 20-expression tag
Gln 21-expression tag
Gly 22-expression tag
Pro 23-expression tag
Ala 24-expression tag
Leu 447Pro 447conflict
Pro 475-expression tag
Ala 476-expression tag
Gly 477-expression tag
Leu 478-expression tag
Glu 479-expression tag
Val 480-expression tag
Leu 481-expression tag
Phe 482-expression tag
Gln 483-expression tag
Gly 484-expression tag
Pro 485-expression tag
His 486-expression tag
His 487-expression tag
His 488-expression tag
His 489-expression tag
His 490-expression tag
His 491-expression tag
His 492-expression tag
His 493-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight186554.1
Non-Polymers*Number of molecules15
Total formula weight4840.1
All*Total formula weight191394.3
*Water molecules are not included.

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PDB entries from 2026-04-01

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