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8E3Y

Cryo-EM structure of the VPAC1R-PACAP27-Gs complex

Summary for 8E3Y
Entry DOI10.2210/pdb8e3y/pdb
EMDB information27873
DescriptorGuanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywordsmembrane protein, drug discovery, g protein coupled receptor, signalling
Biological sourceHomo sapiens (human)
More
Total number of polymer chains6
Total formula weight163010.71
Authors
Piper, S.J.,Danev, R.,Sexton, P.,Wootten, D. (deposition date: 2022-08-17, release date: 2022-11-23)
Primary citationPiper, S.J.,Deganutti, G.,Lu, J.,Zhao, P.,Liang, Y.L.,Lu, Y.,Fletcher, M.M.,Hossain, M.A.,Christopoulos, A.,Reynolds, C.A.,Danev, R.,Sexton, P.M.,Wootten, D.
Understanding VPAC receptor family peptide binding and selectivity
Nat Commun, 13:7013-, 2022
Cited by
DOI: 10.1038/s41467-022-34629-3
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (2.3 Å)
Structure validation

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