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PDB: 80 件
4ZJ3
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Crystal structure of cephalexin bound acyl-enzyme intermediate of Val216AcrF mutant TEM1 beta-lactamase from Escherichia coli: E166N and V216AcrF mutant.
分子名称: Beta-lactamase TEM
著者Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, R.C, Schultz, P.G.
登録日2015-04-29
公開日2015-05-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Exploring the potential impact of an expanded genetic code on protein function.
Proc.Natl.Acad.Sci.USA, 112, 2015
5HW1
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Crystal structure of TEM1 beta-lactamase in the presence of 1.2 MPa xenon
分子名称: Beta-lactamase TEM, XENON
著者Roose, B.W, Dmochowski, I.J.
登録日2016-01-28
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 2018
1ERM
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X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHANE BORONIC ACID
分子名称: 1(R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE
著者Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J.
登録日2000-04-06
公開日2000-05-10
最終更新日2012-06-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39, 2000
1FQG
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MOLECULAR STRUCTURE OF THE ACYL-ENZYME INTERMEDIATE IN TEM-1 BETA-LACTAMASE
分子名称: OPEN FORM - PENICILLIN G, TEM-1 BETA-LACTAMASE
著者Strynadka, N.C.
登録日2000-09-05
公開日2000-11-01
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.
Nature, 359, 1992
8DE0
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TEM-1 beta-lactamase covalently bound to avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase TEM
著者Ji, Z, Boxer, S.G, Mathews, I.I.
登録日2022-06-19
公開日2022-09-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases.
J.Am.Chem.Soc., 144, 2022
1JTG
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CRYSTAL STRUCTURE OF TEM-1 BETA-LACTAMASE / BETA-LACTAMASE INHIBITOR PROTEIN COMPLEX
分子名称: BETA-LACTAMASE INHIBITORY PROTEIN, BETA-LACTAMASE TEM, CALCIUM ION
著者Strynadka, N.C.J, Jensen, S.E, Alzari, P.M, James, M.N.
登録日2001-08-20
公開日2001-10-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase.
Nat.Struct.Biol., 8, 2001
1JVJ
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CRYSTAL STRUCTURE OF N132A MUTANT OF TEM-1 BETA-LACTAMASE IN COMPLEX WITH A N-FORMIMIDOYL-THIENAMYCINE
分子名称: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, BETA-LACTAMASE TEM, POTASSIUM ION
著者Wang, X, Minasov, G, Shoichet, B.K.
登録日2001-08-30
公開日2002-03-06
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Noncovalent interaction energies in covalent complexes: TEM-1 beta-lactamase and beta-lactams.
Proteins, 47, 2002
5I52
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Crystal structure of TEM1 beta-lactamase mutant I263N
分子名称: Beta-lactamase TEM
著者Roose, B.W, Dmochowski, I.J.
登録日2016-02-13
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 2018
1JWP
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Structure of M182T mutant of TEM-1 beta-lactamase
分子名称: BETA-LACTAMASE TEM, PHOSPHATE ION
著者Wang, X, Minasov, G, Shoichet, B.K.
登録日2001-09-04
公開日2002-06-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
J.Mol.Biol., 320, 2002
1NY0
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Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (NBF)
分子名称: Beta-lactamase TEM, PHOSPHATE ION, POTASSIUM ION, ...
著者Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K.
登録日2003-02-11
公開日2003-08-26
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Recognition and Resistance in TEM beta-lactamase
Biochemistry, 42, 2003
1G6A
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PSE-4 CARBENICILLINASE, R234K MUTANT
分子名称: BETA-LACTAMASE PSE-4, SULFATE ION
著者Lim, D, Sanschagrin, F, Passmore, L, De Castro, L, Levesque, R.C, Strynadka, N.C.J.
登録日2000-11-03
公開日2001-02-21
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies.
Biochemistry, 40, 2001
4ZJ2
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Crystal Structure of p-acrylamido-phenylalanine modified TEM1 beta-lactamase from Escherichia coli :E166N mutant
分子名称: Beta-lactamase TEM
著者Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, C.S, Schultz, P.G.
登録日2015-04-28
公開日2015-05-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Exploring the potential impact of an expanded genetic code on protein function.
Proc.Natl.Acad.Sci.USA, 112, 2015
1BT5
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CRYSTAL STRUCTURE OF THE IMIPENEM INHIBITED TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI
分子名称: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, PROTEIN (BETA-LACTAMASE), SULFATE ION
著者Maveyraud, L, Mourey, L, Pedelacq, J.D, Guillet, V, Kotra, L.K, Mobashery, S, Samama, J.P.
登録日1998-09-02
公開日1999-09-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A Beta-Lactamases from Antibiotic-Resistant Bacteria
J.Am.Chem.Soc., 120, 1998
1BTL
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI TEM1 BETA-LACTAMASE AT 1.8 ANGSTROMS RESOLUTION
分子名称: BETA-LACTAMASE TEM1, SULFATE ION
著者Jelsch, C, Mourey, L, Masson, J.M, Samama, J.P.
登録日1993-11-01
公開日1995-01-26
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of Escherichia coli TEM1 beta-lactamase at 1.8 A resolution.
Proteins, 16, 1993
1JWZ
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Crystal structure of TEM-64 beta-lactamase in complex with a boronic acid inhibitor (105)
分子名称: Beta-lactamase TEM, N-[5-METHYL-3-O-TOLYL-ISOXAZOLE-4-CARBOXYLIC ACID AMIDE] BORONIC ACID
著者Wang, X, Minasov, G, Shoichet, B.K.
登録日2001-09-05
公開日2002-06-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
J.Mol.Biol., 320, 2002
5KKF
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Crystal structure of TEM1 beta-lactamase mutant I263L
分子名称: Beta-lactamase TEM
著者Roose, B.W, Dmochowski, I.J.
登録日2016-06-21
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 2018
1JWV
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Crystal structure of G238A mutant of TEM-1 beta-lactamase in complex with a boronic acid inhibitor (sefb4)
分子名称: BETA-LACTAMASE TEM, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, POTASSIUM ION
著者Wang, X, Minasov, G, Shoichet, B.K.
登録日2001-09-05
公開日2002-06-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
J.Mol.Biol., 320, 2002
6APA
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Crystal structure of TEM1 beta-lactamase mutant I263A
分子名称: Beta-lactamase TEM
著者Roose, B.W, Dmochowski, I.J.
登録日2017-08-17
公開日2018-08-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 20, 2019
1PZO
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TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor
分子名称: Beta-lactamase TEM, N,N-BIS(4-CHLOROBENZYL)-1H-1,2,3,4-TETRAAZOL-5-AMINE
著者Horn, J.R, Shoichet, B.K.
登録日2003-07-14
公開日2004-03-09
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric inhibition through core disruption.
J.Mol.Biol., 336, 2004
1XXM
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The modular architecture of protein-protein binding site
分子名称: Beta-lactamase TEM, Beta-lactamase inhibitory protein, CALCIUM ION
著者Reichmann, D, Rahat, O, Albeck, S, Meged, R, Dym, O, Schreiber, G, Israel Structural Proteomics Center (ISPC)
登録日2004-11-07
公開日2005-01-18
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The modular architecture of protein-protein binding interfaces
Proc.Natl.Acad.Sci.USA, 102, 2005
1NYY
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Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (105)
分子名称: Beta-lactamase TEM, N-[5-METHYL-3-O-TOLYL-ISOXAZOLE-4-CARBOXYLIC ACID AMIDE] BORONIC ACID
著者Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K.
登録日2003-02-14
公開日2003-08-26
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recognition and resistance in TEM beta-lactamase
Biochemistry, 42, 2003
1XPB
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STRUCTURE OF BETA-LACTAMASE TEM1
分子名称: BETA-LACTAMASE, SULFATE ION
著者Fonze, E, Charlier, P.
登録日1997-01-10
公開日1997-04-01
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant.
Acta Crystallogr.,Sect.D, 51, 1995
1ERQ
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X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID
分子名称: 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID, TEM-1 BETA-LACTAMASE
著者Ness, S, Martin, R, Kindler, A.M, Paetzel, M, Gold, M, Jones, J.B, Strynadka, N.C.J.
登録日2000-04-06
公開日2000-05-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39, 2000
3TOI
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Tailoring Enzyme Stability and Exploiting Stability-Trait Linkage by Iterative Truncation and Optimization
分子名称: Ampicillin resistance protein
著者Tam, H.K, Einsle, O.
登録日2011-09-05
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Exploring the Molecular Linkage of Protein Stability Traits for Enzyme Optimization by Iterative Truncation and Evolution.
Biochemistry, 51, 2012
4GKU
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Crystal structure of beta lactamase in PET-15B
分子名称: Beta-lactamase TEM
著者Zhang, Y, Cao, C.
登録日2012-08-13
公開日2012-10-10
実験手法X-RAY DIFFRACTION (1.915 Å)
主引用文献Crystal structure of beta lactamase in PET-15B
To be published

222415

件を2024-07-10に公開中

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