1ERQ

X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID

Summary for 1ERQ

Related1ERM 1ERO
DescriptorTEM-1 BETA-LACTAMASE, 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID (3 entities in total)
Functional Keywordsbeta-lactamase, structure-based design, boronate inhibitor, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight29209.04
Authors
Ness, S.,Martin, R.,Kindler, A.M.,Paetzel, M.,Gold, M.,Jones, J.B.,Strynadka, N.C.J. (deposition date: 2000-04-06, release date: 2000-05-10, Last modification date: 2011-07-13)
Primary citation
Ness, S.,Martin, R.,Kindler, A.M.,Paetzel, M.,Gold, M.,Jensen, S.E.,Jones, J.B.,Strynadka, N.C.
Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39:5312-5321, 2000
PubMed: 10820001 (PDB entries with the same primary citation)
DOI: 10.1021/bi992505b
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1407.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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