1BT5

CRYSTAL STRUCTURE OF THE IMIPENEM INHIBITED TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI

Summary for 1BT5

• Entry DOI: 10.2210/pdb1bt5/pdb
• Descriptor: PROTEIN (BETA-LACTAMASE), SULFATE ION, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, ... (4 entities in total)
• Functional Keywords: hydrolase, beta-lactam degradation
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 30053.94

Authors

Maveyraud, L.,Mourey, L.,Pedelacq, J.D.,Guillet, V.,Kotra, L.K.,Mobashery, S.,Samama, J.P. (deposition date: 1998-09-02, release date: 1999-09-02, Last modification date: 2023-12-27)

• Primary citation: Maveyraud, L.,Mourey, L.,Kotra, L.P.,Pedelacq, J.D.,Guillet, V.,Mobashery, S.,Samama, J.P.; Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A Beta-Lactamases from Antibiotic-Resistant Bacteria; J.Am.Chem.Soc., 120:9748-9752, 1998

Experimental method

X-RAY DIFFRACTION (1.8 Å)