1JWV

Crystal structure of G238A mutant of TEM-1 beta-lactamase in complex with a boronic acid inhibitor (sefb4)

Summary for 1JWV

DescriptorBETA-LACTAMASE TEM, POTASSIUM ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ... (4 entities in total)
Functional Keywordstem-1, beta-lactamase, serine hydrolase, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight29481.64
Authors
Wang, X.,Minasov, G.,Shoichet, B.K. (deposition date: 2001-09-05, release date: 2002-06-05, Last modification date: 2011-07-13)
Primary citation
Wang, X.,Minasov, G.,Shoichet, B.K.
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
J.Mol.Biol., 320:85-95, 2002
PubMed: 12079336 (PDB entries with the same primary citation)
DOI: 10.1016/S0022-2836(02)00400-X
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19670 1.8%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25