8DE0
TEM-1 beta-lactamase covalently bound to avibactam
Summary for 8DE0
| Entry DOI | 10.2210/pdb8de0/pdb |
| Descriptor | Beta-lactamase TEM, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total) |
| Functional Keywords | hydrolase, beta-lactamase, tem, avibactam, hydrolase-inhibitor complex, hydrolase/inhibitor |
| Biological source | Escherichia coli |
| Total number of polymer chains | 4 |
| Total formula weight | 116944.86 |
| Authors | Ji, Z.,Boxer, S.G.,Mathews, I.I. (deposition date: 2022-06-19, release date: 2022-09-07, Last modification date: 2023-10-25) |
| Primary citation | Ji, Z.,Kozuch, J.,Mathews, I.I.,Diercks, C.S.,Shamsudin, Y.,Schulz, M.A.,Boxer, S.G. Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases. J.Am.Chem.Soc., 144:20947-20954, 2022 Cited by PubMed: 36324090DOI: 10.1021/jacs.2c09876 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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