1JWZ
Crystal structure of TEM-64 beta-lactamase in complex with a boronic acid inhibitor (105)
Summary for 1JWZ
| Entry DOI | 10.2210/pdb1jwz/pdb |
| Descriptor | Beta-lactamase TEM, N-[5-METHYL-3-O-TOLYL-ISOXAZOLE-4-CARBOXYLIC ACID AMIDE] BORONIC ACID (3 entities in total) |
| Functional Keywords | tem-64, beta-lactamase, serine hydrolase, evolution, antibiotic resistance, hydrolase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 29136.35 |
| Authors | Wang, X.,Minasov, G.,Shoichet, B.K. (deposition date: 2001-09-05, release date: 2002-06-05, Last modification date: 2023-08-16) |
| Primary citation | Wang, X.,Minasov, G.,Shoichet, B.K. Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs. J.Mol.Biol., 320:85-95, 2002 Cited by PubMed: 12079336DOI: 10.1016/S0022-2836(02)00400-X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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