1JWZ

Crystal structure of TEM-64 beta-lactamase in complex with a boronic acid inhibitor (105)

Summary for 1JWZ
DescriptorBeta-lactamase TEM, N-[5-METHYL-3-O-TOLYL-ISOXAZOLE-4-CARBOXYLIC ACID AMIDE] BORONIC ACID (3 entities in total)
Functional Keywordstem-64, beta-lactamase, serine hydrolase, evolution, antibiotic resistance, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight29136.35
Authors
Wang, X.,Minasov, G.,Shoichet, B.K. (deposition date: 2001-09-05, release date: 2002-06-05, Last modification date: 2011-07-13)
Primary citationMinasov, G.,Shoichet, B.K.,Wang, X.
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
J.Mol.Biol., 320:85-95, 2002
PubMed: 12079336
DOI: 110.1016/S0022-2836(02)00400-X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation
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PDB entries from 2021-06-16