1JVJ

CRYSTAL STRUCTURE OF N132A MUTANT OF TEM-1 BETA-LACTAMASE IN COMPLEX WITH A N-FORMIMIDOYL-THIENAMYCINE

Summary for 1JVJ

Entry DOI	10.2210/pdb1jvj/pdb
Descriptor	BETA-LACTAMASE TEM, POTASSIUM ION, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, ... (4 entities in total)
Functional Keywords	protein stability, tem-1, beta-lactamase, beta-lactam, antibiotic resistance, imipenem, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	29395.82
Authors	Wang, X.,Minasov, G.,Shoichet, B.K. (deposition date: 2001-08-30, release date: 2002-03-06, Last modification date: 2023-08-16)
Primary citation	Wang, X.,Minasov, G.,Shoichet, B.K. Noncovalent interaction energies in covalent complexes: TEM-1 beta-lactamase and beta-lactams. Proteins, 47:86-96, 2002 Cited by PubMed: 11870868 DOI: 10.1002/prot.10058.abs PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation