9GAW
| High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2024-07-29 | Release date: | 2024-08-14 | Last modified: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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9EZ8
| Cryo-EM structure of the icosahedral lumazine synthase from Vicia faba. | Descriptor: | 6,7-dimethyl-8-ribityllumazine synthase | Authors: | Chee, M, Trapani, S, Hoh, F, Lai Kee Him, J, Yvon, M, Blanc, S, Bron, P. | Deposit date: | 2024-04-11 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structure of the icosahedral lumazine synthase from Vicia faba. To Be Published
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8Z99
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9C47
| TRRAP module of the human TIP60 complex | Descriptor: | E1A-binding protein p400, Transformation/transcription domain-associated protein | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | Deposit date: | 2024-06-03 | Release date: | 2024-08-14 | Last modified: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9FQ0
| Human NatA-NAC-MAP1 80S ribosome complex | Descriptor: | 28S rRNA, 5.8S rRNA, 60S ribosomal protein L19, ... | Authors: | Klein, M.A, Wild, K, Sinning, I. | Deposit date: | 2024-06-14 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.67 Å) | Cite: | Multi-protein assemblies orchestrate enzymatic processing of the nascent chain on the 80S ribosome To Be Published
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9CEP
| Caulobacter crescentus FljJN flagellar filament (asymmetrical) | Descriptor: | Flagellin | Authors: | Sanchez, J.C, Montemayor, E.J, Ploscariu, N.T, Parrell, D, Baumgardt, J.K, Yang, J.E, Sibert, B, Cai, K, Wright, E.R. | Deposit date: | 2024-06-26 | Release date: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Direct evidence for multi-flagellin filament stabilization via atomic-level architecture of Caulobacter crescentus flagellar filaments To Be Published
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8ZHJ
| SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C1 symmetry) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | Authors: | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | Deposit date: | 2024-05-11 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (8.45 Å) | Cite: | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZYD
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8YHE
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8YF0
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9BK3
| Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form) | Descriptor: | (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, CHLORIDE ION, L-lactate dehydrogenase A chain, ... | Authors: | Lovell, S, Cooper, A, Battaile, K.P, Sharma, H. | Deposit date: | 2024-04-26 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur.J.Med.Chem., 275, 2024
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9CEM
| Caulobacter crescentus FljJL flagellar filament (asymmetrical) | Descriptor: | Flagellin FljL | Authors: | Sanchez, J.C, Montemayor, E.J, Ploscariu, N.T, Parrell, D, Baumgardt, J.K, Yang, J.E, Sibert, B, Cai, K, Wright, E.R. | Deposit date: | 2024-06-26 | Release date: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Direct evidence for multi-flagellin filament stabilization via atomic-level architecture of Caulobacter crescentus flagellar filaments To Be Published
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8YF1
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9ENE
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8YHD
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8Y8B
| Local structure of HCoV-HKU1C spike in complex with TMPRSS2 and glycan | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Wang, H.F, Zhang, X, Lu, Y.C, Liu, X.C, Sun, L, Yang, H.T. | Deposit date: | 2024-02-06 | Release date: | 2024-07-17 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell, 187, 2024
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9C4G
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9IK1
| Cryo-EM structure of the human P2X3 receptor-compound 26a complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[2-cyclopropyl-7-[[(1~{R})-1-naphthalen-2-ylethyl]amino]-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Kim, S, Kim, G.R, Kim, Y.O, Han, X, Nagel, J, Kim, J, Song, D.I, Muller, C.E, Yoon, M.H, Jin, M.S, Kim, Y.C. | Deposit date: | 2024-06-26 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy. J.Med.Chem., 67, 2024
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9CC3
| Human Mitochondrial LONP1 Stall State + casein | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Endogenous Co-purified substrate modeled as unknown residues, Lon protease homolog, ... | Authors: | Mindrebo, J.T, Lander, G.C. | Deposit date: | 2024-06-20 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism. Biorxiv, 2024
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9FWG
| LSD1/CoREST bound to bomedemstat | Descriptor: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | Authors: | Speranzini, V, Mattevi, A. | Deposit date: | 2024-06-30 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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8Y6V
| Near-atomic structure of icosahedrally averaged jumbo bacteriophage PhiKZ capsid | Descriptor: | gp119, gp120, gp162, ... | Authors: | Yang, Y, Shao, Q, Guo, M, Han, L, Zhao, X, Wang, A, Li, X, Wang, B, Pan, J, Chen, Z, Fokine, A, Sun, L, Fang, Q. | Deposit date: | 2024-02-03 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Capsid structure of bacteriophage Phi KZ provides insights into assembly and stabilization of jumbo phages. Nat Commun, 15, 2024
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9CEF
| Caulobacter crescentus FljN flagellar filament (symmetrized) | Descriptor: | Flagellin FljN | Authors: | Sanchez, J.C, Montemayor, E.J, Ploscariu, N.T, Parrell, D, Baumgardt, J.K, Yang, J.E, Sibert, B, Cai, K, Wright, E.R. | Deposit date: | 2024-06-26 | Release date: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (2.22 Å) | Cite: | Direct evidence for multi-flagellin filament stabilization via atomic-level architecture of Caulobacter crescentus flagellar filaments To Be Published
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9ENF
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9CX6
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9CC0
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