9FWG

LSD1/CoREST bound to bomedemstat

This is a non-PDB format compatible entry.

Summary for 9FWG

• Entry DOI: 10.2210/pdb9fwg/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Bomedemstat FAD adduct (3 entities in total)
• Functional Keywords: bomedemstat, epigenetics, histone demethylase, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 147350.52

Authors

Speranzini, V.,Mattevi, A. (deposition date: 2024-06-30, release date: 2024-07-10)

• Primary citation: Jasmine, S.,Mandl, A.,Krueger, T.E.G.,Dalrymple, S.L.,Antony, L.,Dias, J.,Celatka, C.A.,Tapper, A.E.,Kleppe, M.,Kanayama, M.,Jing, Y.,Speranzini, V.,Wang, Y.Z.,Luo, J.,Trock, B.J.,Denmeade, S.R.,Carducci, M.A.,Mattevi, A.,Rienhoff, H.Y.,Isaacs, J.T.,Brennen, W.N.; Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models.; Prostate, 84:909-921, 2024; PubMed: 38619005; DOI: 10.1158/1078-0432.CCR-20-2380

Experimental method

X-RAY DIFFRACTION (3.2 Å)