8Y8B

Local structure of HCoV-HKU1C spike in complex with TMPRSS2 and glycan

Summary for 8Y8B

• Entry DOI: 10.2210/pdb8y8b/pdb
• EMDB information: 39040
• Descriptor: Spike glycoprotein, Transmembrane protease serine 2, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: hku1c, spike, tmprss2, viral protein
• Biological source: Human coronavirus HKU1 (isolate N5); More
• Total number of polymer chains: 4
• Total formula weight: 370567.31

Authors

Wang, H.F.,Zhang, X.,Lu, Y.C.,Liu, X.C.,Sun, L.,Yang, H.T. (deposition date: 2024-02-06, release date: 2024-07-17)

• Primary citation: Wang, H.,Liu, X.,Zhang, X.,Zhao, Z.,Lu, Y.,Pu, D.,Zhang, Z.,Chen, J.,Wang, Y.,Li, M.,Dong, X.,Duan, Y.,He, Y.,Mao, Q.,Guo, H.,Sun, H.,Zhou, Y.,Yang, Q.,Gao, Y.,Yang, X.,Cao, H.,Guddat, L.,Sun, L.,Rao, Z.,Yang, H.; TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.; Cell, 2024; PubMed: 38964329; DOI: 10.1016/j.cell.2024.06.016

Experimental method