8YF1

Cryo-EM structure of human SV2A in complex with Brivaracetam

Summary for 8YF1

• Entry DOI: 10.2210/pdb8yf1/pdb
• EMDB information: 39207
• Descriptor: Synaptic vesicle glycoprotein 2A, (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide (2 entities in total)
• Functional Keywords: synaptic vesicle glycoprotein 2a, brivaracetam, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 169214.34

Authors

Qu, Q.,Liu, S.,Zhou, Z. (deposition date: 2024-02-23, release date: 2024-06-12, Last modification date: 2025-07-02)

• Primary citation: Liu, S.,Chao, Y.,Zhou, Z.,Yang, C.,Zhu, Z.,Wang, Y.,Qu, Q.; Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A.; Cell Discov, 10:56-56, 2024; PubMed: 38773074; DOI: 10.1038/s41421-024-00686-9

Experimental method

ELECTRON MICROSCOPY (3.38 Å)