8YF1

Cryo-EM structure of human SV2A in complex with Brivaracetam

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Synaptic vesicle glycoprotein 2A	polymer	755	84394.9	2	UniProt (Q7L0J3) Pfam (PF00083) Pfam (PF07690) In PDB	Homo sapiens (human)
2	B, A	(2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide	non-polymer		212.3	2	Chemie (VLX)

Sequence modifications

B, A: 1 - 734 (UniProt: Q7L0J3)

PDB	External Database	Details
Ser 735	-	expression tag
Arg 736	-	expression tag
Leu 737	-	expression tag
Glu 738	-	expression tag
Glu 739	-	expression tag
Glu 740	-	expression tag
Leu 741	-	expression tag
Arg 742	-	expression tag
Arg 743	-	expression tag
Arg 744	-	expression tag
Thr 745	-	expression tag
Glu 746	-	expression tag
Pro 747	-	expression tag
Gly 748	-	expression tag
Ser 749	-	expression tag
Leu 750	-	expression tag
Glu 751	-	expression tag
Val 752	-	expression tag
Leu 753	-	expression tag
Phe 754	-	expression tag
Gln 755	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	168789.8
Non-Polymers*	Number of molecules	2
	Total formula weight	424.6
All*	Total formula weight	169214.3

*Water molecules are not included.