9IK1

Cryo-EM structure of the human P2X3 receptor-compound 26a complex

This is a non-PDB format compatible entry.

Summary for 9IK1

• Entry DOI: 10.2210/pdb9ik1/pdb
• EMDB information: 60647
• Descriptor: P2X purinoceptor 3, 4-[2-cyclopropyl-7-[[(1~{R})-1-naphthalen-2-ylethyl]amino]-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: p2x3 receptor, compound 26a, cryo-em, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 126075.52

Authors

Kim, S.,Kim, G.R.,Kim, Y.O.,Han, X.,Nagel, J.,Kim, J.,Song, D.I.,Muller, C.E.,Yoon, M.H.,Jin, M.S.,Kim, Y.C. (deposition date: 2024-06-26, release date: 2024-09-04)

• Primary citation: Kim, G.R.,Kim, S.,Kim, Y.O.,Han, X.,Nagel, J.,Kim, J.,Song, D.I.,Muller, C.E.,Yoon, M.H.,Jin, M.S.,Kim, Y.C.; Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.; J.Med.Chem., 67:14443-14465, 2024; PubMed: 39102524; DOI: 10.1021/acs.jmedchem.4c01214

Experimental method

ELECTRON MICROSCOPY (2.61 Å)