9CX6

Cryo-EM filament structure in FTLD-synuclein

Summary for 9CX6

• Entry DOI: 10.2210/pdb9cx6/pdb
• EMDB information: 45979
• Descriptor: Alpha-synuclein (2 entities in total)
• Functional Keywords: amyloid, filament, synuclein, human brain, cryo-em, fibril, msa, ftld, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 28952.22

Authors

Yang, Y.,Scheres, H.W.S.,Goedert, M. (deposition date: 2024-07-30, release date: 2024-08-14, Last modification date: 2025-09-03)

Primary citation

Cullinane, P.W.,Yang, Y.,Chelban, V.,Goh, Y.Y.,Ebanks, K.,Curless, T.,Wrigley, S.,de Pablo-Fernandez, E.,Holton, J.,Peak-Chew, S.,Franco, C.,Woerman, A.L.,Houlden, H.,Warner, T.T.,Scheres, S.H.W.,Goedert, M.,Jaunmuktane, Z.
Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy.
Neuropathol Appl Neurobiol, 51:e70013-e70013, 2025

PubMed Abstract: The aim of this study is to identify the prevalence of frontotemporal dementia (FTD)/corticobasal syndrome (CBS) in a large cohort of pathologically confirmed cases of multiple system atrophy (MSA) and to determine the α-synuclein seeding characteristics and electron cryo-microscopy (cryo-EM) filament structure in frontotemporal lobar degeneration with MSA-type α-synuclein pathology (FTLD-synuclein).

PubMed: 40135351
DOI: 10.1111/nan.70013

Experimental method

ELECTRON MICROSCOPY (3.2 Å)