9CX6

Cryo-EM filament structure in FTLD-synuclein

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000149	molecular_function	SNARE binding
G	0000287	molecular_function	magnesium ion binding
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001774	biological_process	microglial cell activation
G	0001921	biological_process	positive regulation of receptor recycling
G	0001956	biological_process	positive regulation of neurotransmitter secretion
G	0001963	biological_process	synaptic transmission, dopaminergic
G	0003779	molecular_function	actin binding
G	0004857	molecular_function	enzyme inhibitor activity
G	0004860	molecular_function	protein kinase inhibitor activity
G	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
G	0005504	molecular_function	fatty acid binding
G	0005507	molecular_function	copper ion binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005640	cellular_component	nuclear outer membrane
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005743	cellular_component	mitochondrial inner membrane
G	0005759	cellular_component	mitochondrial matrix
G	0005764	cellular_component	lysosome
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005938	cellular_component	cell cortex
G	0006631	biological_process	fatty acid metabolic process
G	0006638	biological_process	neutral lipid metabolic process
G	0006644	biological_process	phospholipid metabolic process
G	0006749	biological_process	glutathione metabolic process
G	0007006	biological_process	mitochondrial membrane organization
G	0007268	biological_process	chemical synaptic transmission
G	0007269	biological_process	neurotransmitter secretion
G	0008017	molecular_function	microtubule binding
G	0008021	cellular_component	synaptic vesicle
G	0008047	molecular_function	enzyme activator activity
G	0008198	molecular_function	ferrous iron binding
G	0008270	molecular_function	zinc ion binding
G	0008289	molecular_function	lipid binding
G	0008344	biological_process	adult locomotory behavior
G	0009410	biological_process	response to xenobiotic stimulus
G	0010040	biological_process	response to iron(II) ion
G	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
G	0014048	biological_process	regulation of glutamate secretion
G	0014059	biological_process	regulation of dopamine secretion
G	0015629	cellular_component	actin cytoskeleton
G	0016020	cellular_component	membrane
G	0016079	biological_process	synaptic vesicle exocytosis
G	0016082	biological_process	synaptic vesicle priming
G	0016234	cellular_component	inclusion body
G	0016491	molecular_function	oxidoreductase activity
G	0019894	molecular_function	kinesin binding
G	0019899	molecular_function	enzyme binding
G	0019904	molecular_function	protein domain specific binding
G	0030424	cellular_component	axon
G	0030426	cellular_component	growth cone
G	0030544	molecular_function	Hsp70 protein binding
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0030672	cellular_component	synaptic vesicle membrane
G	0031092	cellular_component	platelet alpha granule membrane
G	0031115	biological_process	negative regulation of microtubule polymerization
G	0031623	biological_process	receptor internalization
G	0031648	biological_process	protein destabilization
G	0032026	biological_process	response to magnesium ion
G	0032496	biological_process	response to lipopolysaccharide
G	0032991	cellular_component	protein-containing complex
G	0034341	biological_process	response to type II interferon
G	0034599	biological_process	cellular response to oxidative stress
G	0035493	biological_process	SNARE complex assembly
G	0035543	biological_process	positive regulation of SNARE complex assembly
G	0040012	biological_process	regulation of locomotion
G	0042220	biological_process	response to cocaine
G	0042393	molecular_function	histone binding
G	0042416	biological_process	dopamine biosynthetic process
G	0042417	biological_process	dopamine metabolic process
G	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
G	0042802	molecular_function	identical protein binding
G	0042995	cellular_component	cell projection
G	0043014	molecular_function	alpha-tubulin binding
G	0043025	cellular_component	neuronal cell body
G	0043030	biological_process	regulation of macrophage activation
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043195	cellular_component	terminal bouton
G	0043274	molecular_function	phospholipase binding
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0043679	cellular_component	axon terminus
G	0044344	biological_process	cellular response to fibroblast growth factor stimulus
G	0045202	cellular_component	synapse
G	0045807	biological_process	positive regulation of endocytosis
G	0045920	biological_process	negative regulation of exocytosis
G	0045921	biological_process	positive regulation of exocytosis
G	0045963	biological_process	negative regulation of dopamine metabolic process
G	0046872	molecular_function	metal ion binding
G	0046928	biological_process	regulation of neurotransmitter secretion
G	0048148	biological_process	behavioral response to cocaine
G	0048156	molecular_function	tau protein binding
G	0048168	biological_process	regulation of neuronal synaptic plasticity
G	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048487	molecular_function	beta-tubulin binding
G	0048488	biological_process	synaptic vesicle endocytosis
G	0048489	biological_process	synaptic vesicle transport
G	0050729	biological_process	positive regulation of inflammatory response
G	0050806	biological_process	positive regulation of synaptic transmission
G	0050808	biological_process	synapse organization
G	0050812	biological_process	regulation of acyl-CoA biosynthetic process
G	0051219	molecular_function	phosphoprotein binding
G	0051259	biological_process	protein complex oligomerization
G	0051262	biological_process	protein tetramerization
G	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
G	0051402	biological_process	neuron apoptotic process
G	0051583	biological_process	dopamine uptake involved in synaptic transmission
G	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
G	0051612	biological_process	negative regulation of serotonin uptake
G	0051621	biological_process	regulation of norepinephrine uptake
G	0051622	biological_process	negative regulation of norepinephrine uptake
G	0055074	biological_process	calcium ion homeostasis
G	0060079	biological_process	excitatory postsynaptic potential
G	0060090	molecular_function	molecular adaptor activity
G	0060291	biological_process	long-term synaptic potentiation
G	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
G	0060961	molecular_function	phospholipase D inhibitor activity
G	0061024	biological_process	membrane organization
G	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
G	0070507	biological_process	regulation of microtubule cytoskeleton organization
G	0070555	biological_process	response to interleukin-1
G	0070840	molecular_function	dynein complex binding
G	0071280	biological_process	cellular response to copper ion
G	0071872	biological_process	cellular response to epinephrine stimulus
G	0097435	biological_process	supramolecular fiber organization
G	0098793	cellular_component	presynapse
G	0098794	cellular_component	postsynapse
G	0099512	cellular_component	supramolecular fiber
G	0140311	molecular_function	protein sequestering activity
G	0141108	molecular_function	transporter regulator activity
G	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
G	1903136	molecular_function	cuprous ion binding
G	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
G	1903421	biological_process	regulation of synaptic vesicle recycling
G	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
G	1904307	biological_process	response to desipramine
G	1904377	biological_process	positive regulation of protein localization to cell periphery
G	1904715	biological_process	negative regulation of chaperone-mediated autophagy
G	1905606	biological_process	regulation of presynapse assembly
G	1990000	biological_process	amyloid fibril formation
G	2000377	biological_process	regulation of reactive oxygen species metabolic process
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000149	molecular_function	SNARE binding
H	0000287	molecular_function	magnesium ion binding
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0001774	biological_process	microglial cell activation
H	0001921	biological_process	positive regulation of receptor recycling
H	0001956	biological_process	positive regulation of neurotransmitter secretion
H	0001963	biological_process	synaptic transmission, dopaminergic
H	0003779	molecular_function	actin binding
H	0004857	molecular_function	enzyme inhibitor activity
H	0004860	molecular_function	protein kinase inhibitor activity
H	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
H	0005504	molecular_function	fatty acid binding
H	0005507	molecular_function	copper ion binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005640	cellular_component	nuclear outer membrane
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005743	cellular_component	mitochondrial inner membrane
H	0005759	cellular_component	mitochondrial matrix
H	0005764	cellular_component	lysosome
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005938	cellular_component	cell cortex
H	0006631	biological_process	fatty acid metabolic process
H	0006638	biological_process	neutral lipid metabolic process
H	0006644	biological_process	phospholipid metabolic process
H	0006749	biological_process	glutathione metabolic process
H	0007006	biological_process	mitochondrial membrane organization
H	0007268	biological_process	chemical synaptic transmission
H	0007269	biological_process	neurotransmitter secretion
H	0008017	molecular_function	microtubule binding
H	0008021	cellular_component	synaptic vesicle
H	0008047	molecular_function	enzyme activator activity
H	0008198	molecular_function	ferrous iron binding
H	0008270	molecular_function	zinc ion binding
H	0008289	molecular_function	lipid binding
H	0008344	biological_process	adult locomotory behavior
H	0009410	biological_process	response to xenobiotic stimulus
H	0010040	biological_process	response to iron(II) ion
H	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
H	0014048	biological_process	regulation of glutamate secretion
H	0014059	biological_process	regulation of dopamine secretion
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016079	biological_process	synaptic vesicle exocytosis
H	0016082	biological_process	synaptic vesicle priming
H	0016234	cellular_component	inclusion body
H	0016491	molecular_function	oxidoreductase activity
H	0019894	molecular_function	kinesin binding
H	0019899	molecular_function	enzyme binding
H	0019904	molecular_function	protein domain specific binding
H	0030424	cellular_component	axon
H	0030426	cellular_component	growth cone
H	0030544	molecular_function	Hsp70 protein binding
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0030672	cellular_component	synaptic vesicle membrane
H	0031092	cellular_component	platelet alpha granule membrane
H	0031115	biological_process	negative regulation of microtubule polymerization
H	0031623	biological_process	receptor internalization
H	0031648	biological_process	protein destabilization
H	0032026	biological_process	response to magnesium ion
H	0032496	biological_process	response to lipopolysaccharide
H	0032991	cellular_component	protein-containing complex
H	0034341	biological_process	response to type II interferon
H	0034599	biological_process	cellular response to oxidative stress
H	0035493	biological_process	SNARE complex assembly
H	0035543	biological_process	positive regulation of SNARE complex assembly
H	0040012	biological_process	regulation of locomotion
H	0042220	biological_process	response to cocaine
H	0042393	molecular_function	histone binding
H	0042416	biological_process	dopamine biosynthetic process
H	0042417	biological_process	dopamine metabolic process
H	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
H	0042802	molecular_function	identical protein binding
H	0042995	cellular_component	cell projection
H	0043014	molecular_function	alpha-tubulin binding
H	0043025	cellular_component	neuronal cell body
H	0043030	biological_process	regulation of macrophage activation
H	0043065	biological_process	positive regulation of apoptotic process
H	0043066	biological_process	negative regulation of apoptotic process
H	0043195	cellular_component	terminal bouton
H	0043274	molecular_function	phospholipase binding
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	0043679	cellular_component	axon terminus
H	0044344	biological_process	cellular response to fibroblast growth factor stimulus
H	0045202	cellular_component	synapse
H	0045807	biological_process	positive regulation of endocytosis
H	0045920	biological_process	negative regulation of exocytosis
H	0045921	biological_process	positive regulation of exocytosis
H	0045963	biological_process	negative regulation of dopamine metabolic process
H	0046872	molecular_function	metal ion binding
H	0046928	biological_process	regulation of neurotransmitter secretion
H	0048148	biological_process	behavioral response to cocaine
H	0048156	molecular_function	tau protein binding
H	0048168	biological_process	regulation of neuronal synaptic plasticity
H	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0048487	molecular_function	beta-tubulin binding
H	0048488	biological_process	synaptic vesicle endocytosis
H	0048489	biological_process	synaptic vesicle transport
H	0050729	biological_process	positive regulation of inflammatory response
H	0050806	biological_process	positive regulation of synaptic transmission
H	0050808	biological_process	synapse organization
H	0050812	biological_process	regulation of acyl-CoA biosynthetic process
H	0051219	molecular_function	phosphoprotein binding
H	0051259	biological_process	protein complex oligomerization
H	0051262	biological_process	protein tetramerization
H	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
H	0051402	biological_process	neuron apoptotic process
H	0051583	biological_process	dopamine uptake involved in synaptic transmission
H	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
H	0051612	biological_process	negative regulation of serotonin uptake
H	0051621	biological_process	regulation of norepinephrine uptake
H	0051622	biological_process	negative regulation of norepinephrine uptake
H	0055074	biological_process	calcium ion homeostasis
H	0060079	biological_process	excitatory postsynaptic potential
H	0060090	molecular_function	molecular adaptor activity
H	0060291	biological_process	long-term synaptic potentiation
H	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
H	0060961	molecular_function	phospholipase D inhibitor activity
H	0061024	biological_process	membrane organization
H	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
H	0070507	biological_process	regulation of microtubule cytoskeleton organization
H	0070555	biological_process	response to interleukin-1
H	0070840	molecular_function	dynein complex binding
H	0071280	biological_process	cellular response to copper ion
H	0071872	biological_process	cellular response to epinephrine stimulus
H	0097435	biological_process	supramolecular fiber organization
H	0098793	cellular_component	presynapse
H	0098794	cellular_component	postsynapse
H	0099512	cellular_component	supramolecular fiber
H	0140311	molecular_function	protein sequestering activity
H	0141108	molecular_function	transporter regulator activity
H	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
H	1903136	molecular_function	cuprous ion binding
H	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
H	1903421	biological_process	regulation of synaptic vesicle recycling
H	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
H	1904307	biological_process	response to desipramine
H	1904377	biological_process	positive regulation of protein localization to cell periphery
H	1904715	biological_process	negative regulation of chaperone-mediated autophagy
H	1905606	biological_process	regulation of presynapse assembly
H	1990000	biological_process	amyloid fibril formation
H	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
G	ASP2
G	HIS50
H	ASP2
H	HIS50

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793

Chain	Residue	Details
G	MET1
H	MET1

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630

Chain	Residue	Details
G	SER87
H	SER87

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833

Chain	Residue	Details
G	TYR125
H	TYR125

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070

Chain	Residue	Details
G	SER129
H	SER129

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