6OL9
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![BU of 6ol9 by Molmil](/molmil-images/mine/6ol9) | Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium | Descriptor: | (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... | Authors: | Vuckovic, Z, Christopoulos, A, Thal, D.M. | Deposit date: | 2019-04-16 | Release date: | 2019-12-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.541 Å) | Cite: | Crystal structure of the M5muscarinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA, 116, 2019
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6ANE
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![BU of 6ane by Molmil](/molmil-images/mine/6ane) | Crystal Structure of Ideonella sakaiensis PET Hydrolase | Descriptor: | MAGNESIUM ION, Poly(ethylene terephthalate) hydrolase | Authors: | Galaz-Davison, P, Sotomayor, M, Parra, L.P, Ramirez-Sarmiento, C.A. | Deposit date: | 2017-08-12 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase. Biophys. J., 114, 2018
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7JR7
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![BU of 7jr7 by Molmil](/molmil-images/mine/7jr7) | Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4 | Descriptor: | ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8, Fab 11F4 heavy chain, ... | Authors: | Huang, C.S, Yu, X, Min, X, Wang, Z, Zhang, H. | Deposit date: | 2020-08-11 | Release date: | 2021-04-07 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies Commun Biol, 4, 2021
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6ANU
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![BU of 6anu by Molmil](/molmil-images/mine/6anu) | Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain | Descriptor: | Actin, cytoplasmic 1, Spectrin beta chain, ... | Authors: | Wang, F, Orlova, A, Avery, A.W, Hays, T.S, Egelman, E.H. | Deposit date: | 2017-08-14 | Release date: | 2017-11-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structural basis for high-affinity actin binding revealed by a beta-III-spectrin SCA5 missense mutation. Nat Commun, 8, 2017
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2MKB
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![BU of 2mkb by Molmil](/molmil-images/mine/2mkb) | |
6IJQ
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![BU of 6ijq by Molmil](/molmil-images/mine/6ijq) | Solution structure of BCL-XL bound to P73-TAD peptide | Descriptor: | Bcl-2-like protein 1,Bcl-2-like protein 1, Tumor protein p73 | Authors: | Yoon, M.-K, Ha, J.-H, Lee, M.-S, Chi, S.-W. | Deposit date: | 2018-10-11 | Release date: | 2018-11-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL. J. Biol. Chem., 293, 2018
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2Z3I
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![BU of 2z3i by Molmil](/molmil-images/mine/2z3i) | Crystal structure of blasticidin S deaminase (BSD) mutant E56Q complexed with substrate | Descriptor: | BLASTICIDIN S, Blasticidin-S deaminase, CACODYLATE ION, ... | Authors: | Kumasaka, T, Yamamoto, M, Furuichi, M, Nakasako, M, Kimura, M, Yamaguchi, I, Ueki, T. | Deposit date: | 2007-06-04 | Release date: | 2007-10-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of blasticidin S deaminase (BSD): implications for dynamic properties of catalytic zinc J.Biol.Chem., 282, 2007
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6AV3
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![BU of 6av3 by Molmil](/molmil-images/mine/6av3) | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-Methyl-6-(2-(5-(3-((methylamino)methyl)phenyl)pyridin-3-yl)ethyl)pyridin-2-amine | Descriptor: | 4-methyl-6-[2-(5-{3-[(methylamino)methyl]phenyl}pyridin-3-yl)ethyl]pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2017-09-01 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
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6OUO
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![BU of 6ouo by Molmil](/molmil-images/mine/6ouo) | RF2 accommodated state bound 70S complex at long incubation time | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Fu, Z, Indrisiunaite, G, Kaledhonkar, S, Shah, B, Sun, M, Chen, B, Grassucci, R.A, Ehrenberg, M, Frank, J. | Deposit date: | 2019-05-05 | Release date: | 2019-06-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Nat Commun, 10, 2019
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6IYX
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![BU of 6iyx by Molmil](/molmil-images/mine/6iyx) | Crystal Structure Analysis of a Eukaryotic Membrane Protein | Descriptor: | BROMIDE ION, CALCIUM ION, Trimeric intracellular cation channel type A | Authors: | Zeng, Y, Wang, X.H, Gao, F, Su, M, Chen, Y.H. | Deposit date: | 2018-12-17 | Release date: | 2019-05-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6IZ5
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6OWH
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![BU of 6owh by Molmil](/molmil-images/mine/6owh) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92 | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase KAT8, ... | Authors: | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | Deposit date: | 2019-05-09 | Release date: | 2020-04-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6OWP
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![BU of 6owp by Molmil](/molmil-images/mine/6owp) | Horse liver F93W alcohol dehydrogenase complexed with NAD and trifluoroethanol | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | Authors: | Plapp, B.V. | Deposit date: | 2019-05-10 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer. Biochemistry, 59, 2020
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6OM6
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![BU of 6om6 by Molmil](/molmil-images/mine/6om6) | Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Hoffer, E.D, Mehrani, A, Keiler, K.C, Stagg, S.M, Dunham, C.M. | Deposit date: | 2019-04-18 | Release date: | 2021-02-10 | Last modified: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun, 12, 2021
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6J1Z
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![BU of 6j1z by Molmil](/molmil-images/mine/6j1z) | WWP2 semi-open conformation | Descriptor: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Liu, Z.H. | Deposit date: | 2018-12-30 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10, 2019
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2Z4E
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6AUE
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![BU of 6aue by Molmil](/molmil-images/mine/6aue) | Artificial Metalloproteins Containing a Co4O4 Active Site - 2xm-S112Y-b | Descriptor: | N-biotin-C-Co4(mu3-O)4(OAc)(Py)4(H2O)3-beta-alanine, Streptavidin | Authors: | Olshansky, L, Vallapurakal, J, Huerta-Lavorie, R, Nguyen, A.I, Tilley, T.D, Borovik, A.S. | Deposit date: | 2017-08-31 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Artificial Metalloproteins Containing Co J. Am. Chem. Soc., 140, 2018
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2Z5J
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![BU of 2z5j by Molmil](/molmil-images/mine/2z5j) | Free Transportin 1 | Descriptor: | Transportin-1 | Authors: | Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M. | Deposit date: | 2007-07-13 | Release date: | 2007-10-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for substrate recognition and dissociation by human transportin 1 Mol.Cell, 28, 2007
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6AV1
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![BU of 6av1 by Molmil](/molmil-images/mine/6av1) | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(Dimethylamino)propyl)-5-fluorophenethyl)-4-methylpyridin-2-amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine, Nitric oxide synthase, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2017-09-01 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
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7K4M
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![BU of 7k4m by Molmil](/molmil-images/mine/7k4m) | Crystal structure of MetAP2 Modified Hemoglobin S | Descriptor: | CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | Authors: | Musayev, F.N, Safo, M.K, Light, D.R. | Deposit date: | 2020-09-15 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease. Blood Adv, 5, 2021
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6IZ6
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![BU of 6iz6 by Molmil](/molmil-images/mine/6iz6) | Crystal Structure Analysis of TRIC counter-ion channels in calcium release | Descriptor: | CALCIUM ION, Trimeric intracellular cation channel type B-B | Authors: | Liu, X.L, Wang, X.H, Su, M, Hendrickson, W.A, Chen, Y.H. | Deposit date: | 2018-12-18 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.293 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6IZF
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![BU of 6izf by Molmil](/molmil-images/mine/6izf) | Structural basis for activity of TRIC counter-ion channels in calcium release | Descriptor: | (2R)-1-(dodecanoyloxy)-3-hydroxypropan-2-yl (5E,8E,11E)-tetradeca-5,8,11-trienoate, CALCIUM ION, CHLORIDE ION, ... | Authors: | Wang, X.H, Zeng, Y, Su, M, Hendrickson, W.A, Chen, Y.H. | Deposit date: | 2018-12-19 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6AV0
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![BU of 6av0 by Molmil](/molmil-images/mine/6av0) | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-(3-(methylamino)propyl)benzonitrile | Descriptor: | 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-[3-(methylamino)propyl]benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... | Authors: | LI, H, Poulos, T.L. | Deposit date: | 2017-09-01 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
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2M04
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6AWQ
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![BU of 6awq by Molmil](/molmil-images/mine/6awq) | Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ... | Authors: | Coleman, J.A, Gouaux, E. | Deposit date: | 2017-09-06 | Release date: | 2017-10-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.046 Å) | Cite: | Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25, 2018
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