6AWQ

Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site

Summary for 6AWQ

Entry DOI	10.2210/pdb6awq/pdb
Descriptor	Sodium-dependent serotonin transporter, 8B6 antibody FAB heavy chain, 8B6 antibody FAB light chain, ... (8 entities in total)
Functional Keywords	neurotransmitter transporter, antidepressant, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	111478.33
Authors	Coleman, J.A.,Gouaux, E. (deposition date: 2017-09-06, release date: 2017-10-25, Last modification date: 2023-10-04)
Primary citation	Coleman, J.A.,Gouaux, E. Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25:170-175, 2018 Cited by PubMed: 29379174 DOI: 10.1038/s41594-018-0026-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.046 Å)

Structure validation