Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6AWQ

Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0019814cellular_componentimmunoglobulin complex
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
CTYR212-HIS218
site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYicaqNGGGaF
ChainResidueDetails
ATRP103-PHE117
site_idPS00754
Number of Residues21
DetailsNA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLisSFTdqLPWtsCknswNT
ChainResidueDetails
ATYR186-THR206
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues158
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues81
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q7K4Y6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"34851672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LIA","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34851672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7LIA","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5I6X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34851672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MGW","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5I6X","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q7K4Y6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34851672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LIA","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7MGW","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34851672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LIA","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21992875","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by PKG","evidences":[{"source":"PubMed","id":"17913921","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27049939","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

PDB statisticsPDBj update infoContact PDBjnumon