7K4M
Crystal structure of MetAP2 Modified Hemoglobin S
Summary for 7K4M
Entry DOI | 10.2210/pdb7k4m/pdb |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (5 entities in total) |
Functional Keywords | hemoglobin s, inhibitor, antisickling, oxygen transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 10 |
Total formula weight | 162911.96 |
Authors | Musayev, F.N.,Safo, M.K.,Light, D.R. (deposition date: 2020-09-15, release date: 2021-10-13, Last modification date: 2023-10-18) |
Primary citation | Demers, M.,Sturtevant, S.,Guertin, K.R.,Gupta, D.,Desai, K.,Vieira, B.F.,Li, W.,Hicks, A.,Ismail, A.,Goncalves, B.P.,Di Caprio, G.,Schonbrun, E.,Hansen, S.,Musayev, F.N.,Safo, M.K.,Wood, D.K.,Higgins, J.M.,Light, D.R. MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease. Blood Adv, 5:1388-1402, 2021 Cited by PubMed: 33661300DOI: 10.1182/bloodadvances.2020003670 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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