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7K4M

Crystal structure of MetAP2 Modified Hemoglobin S

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005344molecular_functionoxygen carrier activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0005833cellular_componenthemoglobin complex
A0015670biological_processcarbon dioxide transport
A0015671biological_processoxygen transport
A0016020cellular_componentmembrane
A0019825molecular_functionoxygen binding
A0020037molecular_functionheme binding
A0030185biological_processnitric oxide transport
A0031720molecular_functionhaptoglobin binding
A0031838cellular_componenthaptoglobin-hemoglobin complex
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0043177molecular_functionorganic acid binding
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0071682cellular_componentendocytic vesicle lumen
A0072562cellular_componentblood microparticle
A0098869biological_processcellular oxidant detoxification
B0004601molecular_functionperoxidase activity
B0005344molecular_functionoxygen carrier activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0005833cellular_componenthemoglobin complex
B0008217biological_processregulation of blood pressure
B0015670biological_processcarbon dioxide transport
B0015671biological_processoxygen transport
B0019825molecular_functionoxygen binding
B0020037molecular_functionheme binding
B0030185biological_processnitric oxide transport
B0030492molecular_functionhemoglobin binding
B0031720molecular_functionhaptoglobin binding
B0031721molecular_functionhemoglobin alpha binding
B0031838cellular_componenthaptoglobin-hemoglobin complex
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0043177molecular_functionorganic acid binding
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0070293biological_processrenal absorption
B0070527biological_processplatelet aggregation
B0071682cellular_componentendocytic vesicle lumen
B0072562cellular_componentblood microparticle
B0097746biological_processblood vessel diameter maintenance
B0098869biological_processcellular oxidant detoxification
B1904724cellular_componenttertiary granule lumen
B1904813cellular_componentficolin-1-rich granule lumen
C0004601molecular_functionperoxidase activity
C0005344molecular_functionoxygen carrier activity
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005829cellular_componentcytosol
C0005833cellular_componenthemoglobin complex
C0015670biological_processcarbon dioxide transport
C0015671biological_processoxygen transport
C0016020cellular_componentmembrane
C0019825molecular_functionoxygen binding
C0020037molecular_functionheme binding
C0030185biological_processnitric oxide transport
C0031720molecular_functionhaptoglobin binding
C0031838cellular_componenthaptoglobin-hemoglobin complex
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0043177molecular_functionorganic acid binding
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0071682cellular_componentendocytic vesicle lumen
C0072562cellular_componentblood microparticle
C0098869biological_processcellular oxidant detoxification
D0004601molecular_functionperoxidase activity
D0005344molecular_functionoxygen carrier activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005829cellular_componentcytosol
D0005833cellular_componenthemoglobin complex
D0008217biological_processregulation of blood pressure
D0015670biological_processcarbon dioxide transport
D0015671biological_processoxygen transport
D0019825molecular_functionoxygen binding
D0020037molecular_functionheme binding
D0030185biological_processnitric oxide transport
D0030492molecular_functionhemoglobin binding
D0031720molecular_functionhaptoglobin binding
D0031721molecular_functionhemoglobin alpha binding
D0031838cellular_componenthaptoglobin-hemoglobin complex
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0043177molecular_functionorganic acid binding
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0070293biological_processrenal absorption
D0070527biological_processplatelet aggregation
D0071682cellular_componentendocytic vesicle lumen
D0072562cellular_componentblood microparticle
D0097746biological_processblood vessel diameter maintenance
D0098869biological_processcellular oxidant detoxification
D1904724cellular_componenttertiary granule lumen
D1904813cellular_componentficolin-1-rich granule lumen
E0004601molecular_functionperoxidase activity
E0005344molecular_functionoxygen carrier activity
E0005506molecular_functioniron ion binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005829cellular_componentcytosol
E0005833cellular_componenthemoglobin complex
E0015670biological_processcarbon dioxide transport
E0015671biological_processoxygen transport
E0016020cellular_componentmembrane
E0019825molecular_functionoxygen binding
E0020037molecular_functionheme binding
E0030185biological_processnitric oxide transport
E0031720molecular_functionhaptoglobin binding
E0031838cellular_componenthaptoglobin-hemoglobin complex
E0042542biological_processresponse to hydrogen peroxide
E0042744biological_processhydrogen peroxide catabolic process
E0043177molecular_functionorganic acid binding
E0046872molecular_functionmetal ion binding
E0070062cellular_componentextracellular exosome
E0071682cellular_componentendocytic vesicle lumen
E0072562cellular_componentblood microparticle
E0098869biological_processcellular oxidant detoxification
F0004601molecular_functionperoxidase activity
F0005344molecular_functionoxygen carrier activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005829cellular_componentcytosol
F0005833cellular_componenthemoglobin complex
F0008217biological_processregulation of blood pressure
F0015670biological_processcarbon dioxide transport
F0015671biological_processoxygen transport
F0019825molecular_functionoxygen binding
F0020037molecular_functionheme binding
F0030185biological_processnitric oxide transport
F0030492molecular_functionhemoglobin binding
F0031720molecular_functionhaptoglobin binding
F0031721molecular_functionhemoglobin alpha binding
F0031838cellular_componenthaptoglobin-hemoglobin complex
F0042542biological_processresponse to hydrogen peroxide
F0042744biological_processhydrogen peroxide catabolic process
F0043177molecular_functionorganic acid binding
F0045429biological_processpositive regulation of nitric oxide biosynthetic process
F0046872molecular_functionmetal ion binding
F0070062cellular_componentextracellular exosome
F0070293biological_processrenal absorption
F0070527biological_processplatelet aggregation
F0071682cellular_componentendocytic vesicle lumen
F0072562cellular_componentblood microparticle
F0097746biological_processblood vessel diameter maintenance
F0098869biological_processcellular oxidant detoxification
F1904724cellular_componenttertiary granule lumen
F1904813cellular_componentficolin-1-rich granule lumen
G0004601molecular_functionperoxidase activity
G0005344molecular_functionoxygen carrier activity
G0005506molecular_functioniron ion binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005829cellular_componentcytosol
G0005833cellular_componenthemoglobin complex
G0015670biological_processcarbon dioxide transport
G0015671biological_processoxygen transport
G0016020cellular_componentmembrane
G0019825molecular_functionoxygen binding
G0020037molecular_functionheme binding
G0030185biological_processnitric oxide transport
G0031720molecular_functionhaptoglobin binding
G0031838cellular_componenthaptoglobin-hemoglobin complex
G0042542biological_processresponse to hydrogen peroxide
G0042744biological_processhydrogen peroxide catabolic process
G0043177molecular_functionorganic acid binding
G0046872molecular_functionmetal ion binding
G0070062cellular_componentextracellular exosome
G0071682cellular_componentendocytic vesicle lumen
G0072562cellular_componentblood microparticle
G0098869biological_processcellular oxidant detoxification
H0004601molecular_functionperoxidase activity
H0005344molecular_functionoxygen carrier activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005829cellular_componentcytosol
H0005833cellular_componenthemoglobin complex
H0008217biological_processregulation of blood pressure
H0015670biological_processcarbon dioxide transport
H0015671biological_processoxygen transport
H0019825molecular_functionoxygen binding
H0020037molecular_functionheme binding
H0030185biological_processnitric oxide transport
H0030492molecular_functionhemoglobin binding
H0031720molecular_functionhaptoglobin binding
H0031721molecular_functionhemoglobin alpha binding
H0031838cellular_componenthaptoglobin-hemoglobin complex
H0042542biological_processresponse to hydrogen peroxide
H0042744biological_processhydrogen peroxide catabolic process
H0043177molecular_functionorganic acid binding
H0045429biological_processpositive regulation of nitric oxide biosynthetic process
H0046872molecular_functionmetal ion binding
H0070062cellular_componentextracellular exosome
H0070293biological_processrenal absorption
H0070527biological_processplatelet aggregation
H0071682cellular_componentendocytic vesicle lumen
H0072562cellular_componentblood microparticle
H0097746biological_processblood vessel diameter maintenance
H0098869biological_processcellular oxidant detoxification
H1904724cellular_componenttertiary granule lumen
H1904813cellular_componentficolin-1-rich granule lumen
I0004601molecular_functionperoxidase activity
I0005344molecular_functionoxygen carrier activity
I0005506molecular_functioniron ion binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005829cellular_componentcytosol
I0005833cellular_componenthemoglobin complex
I0015670biological_processcarbon dioxide transport
I0015671biological_processoxygen transport
I0016020cellular_componentmembrane
I0019825molecular_functionoxygen binding
I0020037molecular_functionheme binding
I0030185biological_processnitric oxide transport
I0031720molecular_functionhaptoglobin binding
I0031838cellular_componenthaptoglobin-hemoglobin complex
I0042542biological_processresponse to hydrogen peroxide
I0042744biological_processhydrogen peroxide catabolic process
I0043177molecular_functionorganic acid binding
I0046872molecular_functionmetal ion binding
I0070062cellular_componentextracellular exosome
I0071682cellular_componentendocytic vesicle lumen
I0072562cellular_componentblood microparticle
I0098869biological_processcellular oxidant detoxification
J0004601molecular_functionperoxidase activity
J0005344molecular_functionoxygen carrier activity
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005829cellular_componentcytosol
J0005833cellular_componenthemoglobin complex
J0008217biological_processregulation of blood pressure
J0015670biological_processcarbon dioxide transport
J0015671biological_processoxygen transport
J0019825molecular_functionoxygen binding
J0020037molecular_functionheme binding
J0030185biological_processnitric oxide transport
J0030492molecular_functionhemoglobin binding
J0031720molecular_functionhaptoglobin binding
J0031721molecular_functionhemoglobin alpha binding
J0031838cellular_componenthaptoglobin-hemoglobin complex
J0042542biological_processresponse to hydrogen peroxide
J0042744biological_processhydrogen peroxide catabolic process
J0043177molecular_functionorganic acid binding
J0045429biological_processpositive regulation of nitric oxide biosynthetic process
J0046872molecular_functionmetal ion binding
J0070062cellular_componentextracellular exosome
J0070293biological_processrenal absorption
J0070527biological_processplatelet aggregation
J0071682cellular_componentendocytic vesicle lumen
J0072562cellular_componentblood microparticle
J0097746biological_processblood vessel diameter maintenance
J0098869biological_processcellular oxidant detoxification
J1904724cellular_componenttertiary granule lumen
J1904813cellular_componentficolin-1-rich granule lumen
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING:
ChainResidueDetails
BVAL1
FHIS2
FLYS82
FHIS143
HVAL1
HHIS2
HLYS82
HHIS143
JVAL1
JHIS2
JLYS82
BHIS2
JHIS143
BLYS82
BHIS143
DVAL1
DHIS2
DLYS82
DHIS143
FVAL1

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: distal binding residue
ChainResidueDetails
BHIS63
DHIS63
FHIS63
HHIS63
JHIS63

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: proximal binding residue
ChainResidueDetails
BHIS92
ALEU91
ALEU106
ATHR108
AVAL121
ASER133
CTHR8
CALA13
CTYR24
CLEU29
CHIS45
DHIS92
CASP47
CSER52
CVAL55
CGLY59
CLEU91
CLEU106
CTHR108
CVAL121
CSER133
ETHR8
FHIS92
EALA13
ETYR24
ELEU29
EHIS45
EASP47
ESER52
EVAL55
EGLY59
ELEU91
ELEU106
HHIS92
ETHR108
EVAL121
ESER133
GTHR8
GALA13
GTYR24
GLEU29
GHIS45
GASP47
GSER52
JHIS92
GVAL55
GGLY59
GLEU91
GLEU106
GTHR108
GVAL121
GSER133
ITHR8
IALA13
ITYR24
AASP47
ILEU29
IHIS45
IASP47
ISER52
IVAL55
IGLY59
ILEU91
ILEU106
ITHR108
IVAL121
ASER52
ISER133
AVAL55
AGLY59

site_idSWS_FT_FI4
Number of Residues95
DetailsSITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
ChainResidueDetails
BGLU7
BGLY74
BTHR84
BHIS92
BARG104
BLEU110
BGLY119
BPHE122
BALA128
BALA140
BLYS144
BGLY25
DGLU7
DGLY25
DGLY29
DTYR35
DTRP37
DPHE45
DASP52
DGLY56
DPHE71
DGLY74
BGLY29
DTHR84
DHIS92
DARG104
DLEU110
DGLY119
DPHE122
DALA128
DALA140
DLYS144
FGLU7
BTYR35
FGLY25
FGLY29
FTYR35
FTRP37
FPHE45
FASP52
FGLY56
FPHE71
FGLY74
FTHR84
BTRP37
FHIS92
FARG104
FLEU110
FGLY119
FPHE122
FALA128
FALA140
FLYS144
HGLU7
HGLY25
BPHE45
HGLY29
HTYR35
HTRP37
HPHE45
HASP52
HGLY56
HPHE71
HGLY74
HTHR84
HHIS92
BASP52
HARG104
HLEU110
HGLY119
HPHE122
HALA128
HALA140
HLYS144
JGLU7
JGLY25
JGLY29
BGLY56
JTYR35
JTRP37
JPHE45
JASP52
JGLY56
JPHE71
JGLY74
JTHR84
JHIS92
JARG104
BPHE71
JLEU110
JGLY119
JPHE122
JALA128
JALA140
JLYS144

site_idSWS_FT_FI5
Number of Residues15
DetailsSITE: Not glycated => ECO:0000269|PubMed:7358733
ChainResidueDetails
BLYS59
HLYS59
HLYS82
HLYS95
JLYS59
JLYS82
JLYS95
BLYS82
BLYS95
DLYS59
DLYS82
DLYS95
FLYS59
FLYS82
FLYS95

site_idSWS_FT_FI6
Number of Residues5
DetailsMOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b
ChainResidueDetails
BVAL1
GLYS7
GLYS16
GLYS40
ILYS7
ILYS16
ILYS40
DVAL1
FVAL1
HVAL1
JVAL1
CLYS40
ELYS7
ELYS16
ELYS40

site_idSWS_FT_FI7
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER9
JSER44
BSER44
DSER9
DSER44
FSER9
FSER44
HSER9
HSER44
JSER9

site_idSWS_FT_FI8
Number of Residues15
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BTHR12
HTHR12
HTHR50
HTHR87
JTHR12
JTHR50
JTHR87
BTHR50
BTHR87
DTHR12
DTHR50
DTHR87
FTHR12
FTHR50
FTHR87

site_idSWS_FT_FI9
Number of Residues10
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009
ChainResidueDetails
BLYS59
JLYS82
BLYS82
DLYS59
DLYS82
FLYS59
FLYS82
HLYS59
HLYS82
JLYS59

site_idSWS_FT_FI10
Number of Residues5
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
ChainResidueDetails
BCYS93
ESER124
ESER131
ESER138
GSER102
GSER124
GSER131
GSER138
ISER102
ISER124
ISER131
DCYS93
ISER138
FCYS93
HCYS93
JCYS93
CSER124
CSER131
CSER138
ESER102

site_idSWS_FT_FI11
Number of Residues5
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
ChainResidueDetails
BLYS144
GTHR108
GTHR134
GTHR137
ITHR108
ITHR134
ITHR137
DLYS144
FLYS144
HLYS144
JLYS144
CTHR137
ETHR108
ETHR134
ETHR137

site_idSWS_FT_FI12
Number of Residues5
DetailsCARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
ChainResidueDetails
BVAL1
GLYS7
GLYS16
GLYS40
ILYS7
ILYS16
ILYS40
DVAL1
FVAL1
HVAL1
JVAL1
CLYS40
ELYS7
ELYS16
ELYS40

site_idSWS_FT_FI13
Number of Residues20
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
ChainResidueDetails
BLYS8
FLYS17
FLYS66
FLYS120
HLYS8
HLYS17
HLYS66
HLYS120
JLYS8
JLYS17
JLYS66
BLYS17
JLYS120
BLYS66
BLYS120
DLYS8
DLYS17
DLYS66
DLYS120
FLYS8

site_idSWS_FT_FI14
Number of Residues5
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
ChainResidueDetails
BLYS144
DLYS144
FLYS144
HLYS144
JLYS144

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PDB entries from 2024-08-14

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