6OL9

Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium

Summary for 6OL9

Entry DOI	10.2210/pdb6ol9/pdb
Descriptor	Muscarinic acetylcholine receptor M5, T4 Lysozyme fusion, OLEIC ACID, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ... (6 entities in total)
Functional Keywords	gpcr inhibitor complex, membrane protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	56733.95
Authors	Vuckovic, Z.,Christopoulos, A.,Thal, D.M. (deposition date: 2019-04-16, release date: 2019-12-11, Last modification date: 2023-10-11)
Primary citation	Vuckovic, Z.,Gentry, P.R.,Berizzi, A.E.,Hirata, K.,Varghese, S.,Thompson, G.,van der Westhuizen, E.T.,Burger, W.A.C.,Rahmani, R.,Valant, C.,Langmead, C.J.,Lindsley, C.W.,Baell, J.B.,Tobin, A.B.,Sexton, P.M.,Christopoulos, A.,Thal, D.M. Crystal structure of the M5muscarinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA, 116:26001-26007, 2019 Cited by PubMed: 31772027 DOI: 10.1073/pnas.1914446116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.541 Å)

Structure validation