6OL9
Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue OLA A 1201 |
| Chain | Residue |
| A | VAL490 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue OLA A 1202 |
| Chain | Residue |
| A | ASN115 |
| A | MET119 |
| A | PRO164 |
| A | ALA165 |
| A | CYS168 |
| A | TRP169 |
| A | LEU172 |
| A | ALA200 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue 0HK A 1203 |
| Chain | Residue |
| A | ASP110 |
| A | TYR111 |
| A | SER114 |
| A | ASN115 |
| A | THR194 |
| A | THR197 |
| A | ALA198 |
| A | PHE202 |
| A | TRP455 |
| A | TYR458 |
| A | ASN459 |
| A | TYR481 |
| A | CYS484 |
| A | TYR485 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue P33 A 1204 |
| Chain | Residue |
| A | TYR87 |
| A | TYR111 |
| A | CYS183 |
| A | GLN184 |
| A | ILE185 |
| A | LEU188 |
| A | SER189 |
| A | TRP477 |
| A | HIS478 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue OLC A 1205 |
| Chain | Residue |
| A | LYS62 |
| A | TYR67 |
| A | PRO144 |
| A | LYS145 |
| A | GLY148 |
| A | PHE159 |
| A | CYS471 |
| A | LEU476 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 9 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
