7JR7

Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4

Summary for 7JR7

• Entry DOI: 10.2210/pdb7jr7/pdb
• EMDB information: 22443
• Descriptor: ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8, Fab 11F4 heavy chain, ... (6 entities in total)
• Functional Keywords: abc transporter, sterol, atp hydrolysis, pump, fab, complex, cholesterol, membrane protein, translocase-immune system complex, translocase/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 243116.05

Authors

Huang, C.S.,Yu, X.,Min, X.,Wang, Z.,Zhang, H. (deposition date: 2020-08-11, release date: 2021-04-07, Last modification date: 2021-05-12)

• Primary citation: Zhang, H.,Huang, C.S.,Yu, X.,Lee, J.,Vaish, A.,Chen, Q.,Zhou, M.,Wang, Z.,Min, X.; Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies; Commun Biol, 4:526-, 2021; DOI: 10.1038/s42003-021-02039-8

Experimental method

ELECTRON MICROSCOPY (3.3 Å)