PDB: 1697 resultsInfo pagesStatus searchChemie searchBIRD

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1UVS	BOVINE THROMBIN--BM51.1011 COMPLEX Descriptor: THROMBIN, [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE Authors: Engh, R.A, Huber, R. Deposit date: 1996-10-16 Release date: 1997-11-19 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. Structure, 4, 1996
1NRQ	CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE D-FPR'S Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1994-01-18 Release date: 1994-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry, 33, 1994
1NRP	CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE NR'S Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1994-01-18 Release date: 1994-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry, 33, 1994
1NRO	CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE NRP Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1994-01-18 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry, 33, 1994
1NRN	CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), RECEPTOR BASED PEPTIDE NRS Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1994-01-18 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry, 33, 1994
1NRS	CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN, ... Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1994-01-18 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry, 33, 1994
4AX9	Human thrombin complexed with Napsagatran, RO0466240 Descriptor: 2-[[(2S)-4-[[(3S)-1-carbamimidoylpiperidin-3-yl]methylamino]-2-(naphthalen-2-ylsulfonylamino)-4-oxidanylidene-butanoyl] -cyclopropyl-amino]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, HIRUDIN VARIANT-1, ... Authors: Banner, D.W, D'Arcy, A, Winkler, F.K, Hilpert, K, Spinelli, S, Cambillau, C. Deposit date: 2012-06-11 Release date: 2012-06-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors. J.Med.Chem., 37, 1994
1FPH	THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), FIBRINOPEPTIDE A, ... Authors: Stubbs, M.T, Bode, W. Deposit date: 1993-04-21 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur.J.Biochem., 206, 1992
1HGT	STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA-THROMBIN Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN Authors: Tulinsky, A, Skrzypczak-Jankun, E. Deposit date: 1991-06-03 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the hirugen and hirulog 1 complexes of alpha-thrombin. J.Mol.Biol., 221, 1991
1HBT	Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), P596 Inhibitor peptide Authors: Rehse, P.H, Cygler, M. Deposit date: 1995-04-06 Release date: 1995-07-10 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin. Biochemistry, 34, 1995
1HLT	THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Tulinsky, A, Mathews, I.I. Deposit date: 1994-08-28 Release date: 1994-12-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin. Biochemistry, 33, 1994
1HUT	THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER Descriptor: ALPHA-Thrombin heavy chain, ALPHA-Thrombin light chain, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ... Authors: Padmanabhan, K, Padmanabhan, K.P, Ferrara, J.D, Sadler, J.E, Tulinsky, A. Deposit date: 1993-05-27 Release date: 1994-06-22 Last modified: 2013-02-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. J.Biol.Chem., 268, 1993
6T57	Thrombin in Complex with a D-Phe-Pro-N-amidinopiperidine Derivative Descriptor: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(1-carbamimidoylpiperidin-4-yl)methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... Authors: Ngo, K, Abazi, N, Heine, A, Klebe, G. Deposit date: 2019-10-15 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Thrombin in Complex with a D-Phe-Pro-N-amidinopiperidine Derivative To Be Published
6T53	Thrombin in Complex with a D-Phe-Pro-p-benzylamine derivative Descriptor: (2~{S})-~{N}-[[4-(aminomethyl)phenyl]methyl]-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... Authors: Ngo, K, Abazi, N, Heine, A, Klebe, G. Deposit date: 2019-10-15 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Thrombin in Complex with a D-Phe-Pro-p-benzylamine derivative To Be Published
6T52	Thrombin in Complex with a D-Phe-Pro-imidazole derivative Descriptor: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[2-(1~{H}-imidazol-4-yl)ethyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... Authors: Ngo, K, Abazi, N, Heine, A, Klebe, G. Deposit date: 2019-10-15 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Thrombin in Complex with a D-Phe-Pro-imidazole derivative To Be Published
6T3M	Thrombin in Complex with a D-Phe-Pro-p-phenol derivative Descriptor: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(4-hydroxyphenyl)methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin variant-2, ... Authors: Ngo, K, Collins, C, Heine, A, Klebe, G. Deposit date: 2019-10-11 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Thrombin in Complex with a D-Phe-Pro-p-phenol derivative To Be Published
6T54	Thrombin in Complex with a D-Phe-Pro-2-bromothiophene Derivative Descriptor: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(5-bromanylthiophen-2-yl)methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... Authors: Ngo, K, Abazi, N, Heine, A, Klebe, G. Deposit date: 2019-10-15 Release date: 2020-11-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Thrombin in Complex with a D-Phe-Pro-2-bromothiophene Derivative To Be Published
1HAO	COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON NMR MODEL OF DNA) Descriptor: ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Tulinsky, A, Padmanabhan, K. Deposit date: 1995-10-03 Release date: 1996-04-03 Last modified: 2013-02-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: An ambiguous structure of a DNA 15-mer thrombin complex. Acta Crystallogr.,Sect.D, 52, 1996
1IHS	CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6 Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUTONIN Authors: Zdanov, A, Cygler, M. Deposit date: 1993-08-04 Release date: 1994-01-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. Proteins, 17, 1993
1IHT	CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6 Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUTONIN-6 Authors: Zdanov, A, Cygler, M. Deposit date: 1993-08-04 Release date: 1994-01-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6. Proteins, 17, 1993
4AYV	Human thrombin - inhibitor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIRUDIN-3A', SODIUM ION, ... Authors: Banner, D.W, D'Arcy, A, Winkler, F.K, Hilpert, K. Deposit date: 2012-06-22 Release date: 2012-08-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors. J.Med.Chem., 37, 1994
1ABI	STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRULOG 3 Authors: Qiu, X, Tulinsky, A. Deposit date: 1992-08-24 Release date: 1994-01-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. Biochemistry, 31, 1992
1ABJ	STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide Authors: Qiu, X, Tulinsky, A. Deposit date: 1992-08-24 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. Biochemistry, 31, 1992
1DWE	Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors Descriptor: ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991
1DWB	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ... Authors: Banner, D.W, Hadvary, P. Deposit date: 1992-08-19 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.16 Å) Cite: Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

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