1ABJ

STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS

Summary for 1ABJ
Related PRD IDPRD_000020
DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (4 entities in total)
Functional Keywordsserine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space: P00734 P00734
Total number of polymer chains2
Total formula weight34330.74
Authors
Qiu, X.,Tulinsky, A. (deposition date: 1992-08-24, release date: 1994-01-31, Last modification date: 2013-02-27)
Primary citationCarperos, V.E.,Fenton 2nd., J.W.,Kline, T.,Maraganore, J.M.,Padmanabhan, K.P.,Qiu, X.,Tulinsky, A.
Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
Biochemistry, 31:11689-11697, 1992
PubMed: 1445905
DOI: 110.1021/bi00162a004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation
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PDB entries from 2021-06-23