7QGF
 
 | | Cubic Insulin SAD phasing at 14.2 keV | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Nanao, M.H, Basu, S. | | Deposit date: | 2021-12-08 | | Release date: | 2022-06-01 | | Method: | X-RAY DIFFRACTION (1.203 Å) | | Cite: | ID23-2: an automated and high-performance microfocus beamline for macromolecular crystallography at the ESRF.
J.Synchrotron Radiat., 29, 2022
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6ZHB
 | | 3D electron diffraction structure of bovine insulin | | Descriptor: | Insulin, ZINC ION | | Authors: | Blum, T, Housset, D, Clabbers, M.T.B, van Genderen, E, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G, Ling, W.L, Abrahams, J.P. | | Deposit date: | 2020-06-22 | | Release date: | 2021-01-27 | | Last modified: | 2024-01-24 | | Method: | ELECTRON CRYSTALLOGRAPHY (3.25 Å) | | Cite: | Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.
Acta Crystallogr D Struct Biol, 77, 2021
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6ZI8
 | | X-ray diffraction structure of bovine insulin at 2.3 A resolution | | Descriptor: | CHLORIDE ION, Insulin, ZINC ION | | Authors: | Housset, D, Ling, W.L, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G. | | Deposit date: | 2020-06-25 | | Release date: | 2021-01-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.
Acta Crystallogr D Struct Biol, 77, 2021
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5HPU
 | | Insulin with proline analog HyP at position B28 in the R6 state | | Descriptor: | CHLORIDE ION, Insulin, chain A, ... | | Authors: | Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. | | Deposit date: | 2016-01-21 | | Release date: | 2017-01-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
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5HRQ
 | | Insulin with proline analog HzP at position B28 in the R6 state | | Descriptor: | CHLORIDE ION, Insulin A-Chain, Insulin B-Chain, ... | | Authors: | Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. | | Deposit date: | 2016-01-24 | | Release date: | 2017-01-25 | | Last modified: | 2020-01-15 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
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6Z7Z
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6X4X
 | | B24Y DKP insulin | | Descriptor: | Insulin, Insulin chain A | | Authors: | Weiss, M.A, Yang, Y. | | Deposit date: | 2020-05-24 | | Release date: | 2020-08-05 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5EMS
 | | Crystal Structure of an iodinated insulin analog | | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | | Authors: | Lawrence, M.C, Pandyarajan, V, Wan, Z, Weiss, M.A. | | Deposit date: | 2015-11-06 | | Release date: | 2016-11-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
J. Biol. Chem., 291, 2016
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5HPR
 | | Insulin with proline analog HyP at position B28 in the T2 state | | Descriptor: | GLYCEROL, Insulin A-Chain, Insulin B-Chain, ... | | Authors: | Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. | | Deposit date: | 2016-01-21 | | Release date: | 2017-01-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
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5HQI
 | | Insulin with proline analog HzP at position B28 in the T2 state | | Descriptor: | Insulin A-Chain, Insulin B-Chain | | Authors: | Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. | | Deposit date: | 2016-01-21 | | Release date: | 2017-01-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
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6S4J
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3E7Z
 | | Structure of human insulin | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Timofeev, V.I, Lyashenko, A.V, Kislitsyn, Y.A, Baidus, A.N, Kuranova, I.P. | | Deposit date: | 2008-08-19 | | Release date: | 2009-02-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of human insulin
To be published
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6S4I
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6RVA
 | | STRUCTURE OF [ASP58]-IGF-I ANALOGUE | | Descriptor: | Insulin-like growth factor I | | Authors: | Jiracek, J, Zakova, L, Socha, O. | | Deposit date: | 2019-05-31 | | Release date: | 2019-10-02 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses.
J.Biol.Chem., 294, 2019
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3EXX
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3FHP
 | | A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution | | Descriptor: | Insulin, ZINC ION | | Authors: | Iwai, W, Kurihara, K, Yamada, T, Kobayashi, Y, Ohnishi, Y, Tanaka, I, Takahashi, H, Niimura, N. | | Deposit date: | 2008-12-09 | | Release date: | 2009-10-20 | | Last modified: | 2023-11-01 | | Method: | NEUTRON DIFFRACTION (2 Å) | | Cite: | A neutron crystallographic analysis of T6 porcine insulin at 2.1 A resolution
Acta Crystallogr.,Sect.D, 65, 2009
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6TC2
 | | Monoclinic human insulin in complex with p-coumaric acid | | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Insulin, PHOSPHATE ION, ... | | Authors: | Triandafillidis, D.-P, Parthenios, N, Spiliopoulou, M, Valmas, A, Kosinas, C, Gozzo, F, Reinle-Schmitt, M, Beckers, D, Degen, T, Pop, M, Fitch, A, Wollenhaupt, J, Weiss, M.S, Karavassili, F, Margiolaki, I. | | Deposit date: | 2019-11-04 | | Release date: | 2020-11-11 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.
Acta Crystallogr D Struct Biol, 76, 2020
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8ONI
 | | Human insulin in complex with the analytical antibody S1 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... | | Authors: | Johansson, E. | | Deposit date: | 2023-04-03 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils
To Be Published
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8PI4
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8PI5
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8PJH
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8PI6
 | | Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension | | Descriptor: | Insulin B chain,Insulin A chain | | Authors: | Johansson, E, Schluckebier, G. | | Deposit date: | 2023-06-21 | | Release date: | 2023-11-08 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
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8PJC
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3E7Y
 | | Structure of human insulin | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Timofeev, V.I, Baidus, A.N, Kislitsyn, Y.A, Kuranova, I.P. | | Deposit date: | 2008-08-19 | | Release date: | 2009-02-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of human insulin
to be published
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8ONK
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