5HQI

Insulin with proline analog HzP at position B28 in the T2 state

Summary for 5HQI

DescriptorInsulin A-Chain, Insulin B-Chain (3 entities in total)
Functional Keywordsinsulin, non-canonical amino acid, hydroxyproline, non-natural amino acid, unnatural amino acid, hormone
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5833.65
Authors
Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Tirrell, D.A. (deposition date: 2016-01-21, release date: 2017-01-25, Last modification date: 2017-07-12)
Primary citation
Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Rawson, J.,LeBon, J.,Ku, H.T.,Tirrell, D.A.
4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139:8384-8387, 2017
PubMed: 28598606 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.7b00794
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (0.97 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1600000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution