5HQI

Insulin with proline analog HzP at position B28 in the T2 state

Summary for 5HQI

DescriptorInsulin A-Chain, Insulin B-Chain (3 entities in total)
Functional Keywordsinsulin, non-canonical amino acid, hydroxyproline, non-natural amino acid, unnatural amino acid, hormone
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight5833.65
Authors
Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Tirrell, D.A. (deposition date: 2016-01-21, release date: 2017-01-25, Last modification date: 2020-01-15)
Primary citation
Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Rawson, J.,LeBon, J.,Ku, H.T.,Tirrell, D.A.
4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139:8384-8387, 2017
PubMed: 28598606 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.7b00794
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (0.97 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1600000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28