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4ATK
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BU of 4atk by Molmil
MITF:E-box complex
Descriptor: 5'-D(*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*T)-3', MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR
Authors:Pogenberg, V, Deineko, V, Wilmanns, M.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Restricted Leucine Zipper Dimerization and Specificity of DNA Recognition of the Melanocyte Master Regulator Mitf
Genes Dev., 26, 2012
4ATI
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BU of 4ati by Molmil
MITF:M-box complex
Descriptor: 5'-D(*AP*GP*GP*GP*TP*CP*AP*TP*GP*TP*GP*CP*TP*AP*AP*C)-3', 5'-D(*GP*TP*TP*AP*GP*CP*AP*CP*AP*TP*GP*AP*CP*CP*CP*T)-3', MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR
Authors:Pogenberg, V, Deineko, V, Wilmanns, M.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Restricted Leucine Zipper Dimerization and Specificity of DNA Recognition of the Melanocyte Master Regulator Mitf
Genes Dev., 26, 2012
4ATH
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BU of 4ath by Molmil
MITF apo structure
Descriptor: MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR, SULFATE ION
Authors:Pogenberg, V, Milewski, M, Wilmanns, M.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Restricted Leucine Zipper Dimerization and Specificity of DNA Recognition of the Melanocyte Master Regulator Mitf
Genes Dev., 26, 2012
1A0A
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BU of 1a0a by Molmil
PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX
Descriptor: DNA (5'-D(*CP*TP*AP*GP*TP*CP*CP*CP*AP*CP*GP*TP*GP*TP*GP*AP*G )-3'), DNA (5'-D(*CP*TP*CP*AP*CP*AP*CP*GP*TP*GP*GP*GP*AP*CP*TP*AP*G )-3'), PROTEIN (PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4)
Authors:Shimizu, T, Toumoto, A, Ihara, K, Shimizu, M, Kyogoku, Y, Ogawa, N, Oshima, Y, Hakoshima, T.
Deposit date:1997-11-27
Release date:1998-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition.
EMBO J., 16, 1997
6FX5
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BU of 6fx5 by Molmil
MITF dimerization mutant
Descriptor: Microphthalmia-associated transcription factor, SULFATE ION
Authors:Pogenberg, V, Milewski, M, Wilmanns, M.
Deposit date:2018-03-08
Release date:2019-03-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif.
Nucleic Acids Res., 48, 2020
6G1L
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BU of 6g1l by Molmil
MITF/CLEARbox structure
Descriptor: CLEAR-box, Microphthalmia-associated transcription factor
Authors:Pogenberg, V, Wilmanns, M.
Deposit date:2018-03-21
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:MITF has a central role in regulating starvation-induced autophagy in melanoma.
Sci Rep, 9, 2019
7F09
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BU of 7f09 by Molmil
Crystal structure of the HLH-Lz domain of human TFE3
Descriptor: 1,2-ETHANEDIOL, Transcription factor E3, ZINC ION
Authors:Yang, G, Li, P, Liu, Z, Wu, S, Zhuang, C, Qiao, H, Fang, P, Wang, J.
Deposit date:2021-06-03
Release date:2021-07-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the dimerization mechanism of human transcription factor E3.
Biochem.Biophys.Res.Commun., 569, 2021
7F2F
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BU of 7f2f by Molmil
The complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae.
Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*CP*AP*TP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*AP*CP*AP*CP*AP*TP*GP*AP*TP*CP*T)-3'), Serine-rich protein TYE7
Authors:Gui, W.
Deposit date:2021-06-10
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021
7EOD
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BU of 7eod by Molmil
MITF HLHLZ Delta AKE
Descriptor: GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor
Authors:Li, P, Liu, Z, Fang, P, Wang, J.
Deposit date:2021-04-22
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7WZ6
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BU of 7wz6 by Molmil
Crystal structure of MyoD-E47
Descriptor: Isoform E47 of Transcription factor E2-alpha, Myoblast determination protein 1
Authors:Zhong, J, Huang, Y, Ma, J.
Deposit date:2022-02-17
Release date:2022-06-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of the bHLH domains of MyoD-E47 heterodimer.
Biochem.Biophys.Res.Commun., 621, 2022
7Y62
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BU of 7y62 by Molmil
Crystal structure of human TFEB HLHLZ domain
Descriptor: Transcription factor EB
Authors:Yang, G, Li, P, Lin, Y, Liu, Z, Sun, H, Zhao, Z, Fang, P, Wang, J.
Deposit date:2022-06-18
Release date:2023-03-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.
Proc.Natl.Acad.Sci.USA, 120, 2023
8IA3
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BU of 8ia3 by Molmil
Crystal structure of human USF2 bHLHLZ domain in complex with DNA
Descriptor: DNA (5'-D(*GP*CP*GP*CP*GP*TP*CP*AP*CP*GP*TP*GP*CP*CP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*GP*GP*CP*AP*CP*GP*TP*GP*AP*CP*GP*CP*GP*C)-3'), Upstream stimulatory factor 2
Authors:Huang, C, Fang, P, Wang, J.
Deposit date:2023-02-07
Release date:2023-09-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain.
J.Biol.Chem., 299, 2023
4F3L
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BU of 4f3l by Molmil
Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
Descriptor: BMAL1b, Circadian locomoter output cycles protein kaput
Authors:Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J.
Deposit date:2012-05-09
Release date:2012-06-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.268 Å)
Cite:Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
7ZUB
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BU of 7zub by Molmil
Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex
Descriptor: (3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one, ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, ...
Authors:Gruszczyk, J, Savva, C.G, Lai-Kee-Him, J, Bous, J, Ancelin, A, Kwong, H.S, Grandvuillemin, L, Bourguet, W.
Deposit date:2022-05-12
Release date:2022-11-23
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.
Nat Commun, 13, 2022
5NJ8
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BU of 5nj8 by Molmil
Structural basis for aryl hydrocarbon receptor mediated gene activation
Descriptor: ACETATE ION, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor nuclear translocator, ...
Authors:Daumke, O, Schulte, K.W.
Deposit date:2017-03-28
Release date:2017-06-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.
Structure, 25, 2017
5Y7Y
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BU of 5y7y by Molmil
Crystal structure of AhRR/ARNT complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL
Authors:Sakurai, S, Shimizu, T, Ohto, U.
Deposit date:2017-08-18
Release date:2017-09-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
J. Biol. Chem., 292, 2017
1UKL
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BU of 1ukl by Molmil
Crystal structure of Importin-beta and SREBP-2 complex
Descriptor: Importin beta-1 subunit, Sterol regulatory element binding protein-2
Authors:Lee, S.J, Sekimoto, T, Yamashita, E, Nagoshi, E, Nakagawa, A, Imamoto, N, Yoshimura, M, Sakai, H, Tsukihara, T, Yoneda, Y.
Deposit date:2003-08-26
Release date:2003-12-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of Importin-beta Bound to SREBP-2: Nuclear Import of a Transcription Factor
Science, 302, 2003
8H77
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BU of 8h77 by Molmil
Hsp90-AhR-p23-XAP2 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ...
Authors:Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F.
Deposit date:2022-10-19
Release date:2023-01-04
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the cytosolic AhR complex.
Structure, 31, 2023
8QMO
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BU of 8qmo by Molmil
Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ...
Authors:Kwong, H.S, Grandvuillemin, L, Sirounian, S, Ancelin, A, Lai-Kee-Him, J, Carivenc, C, Lancey, C, Ragan, T.J, Hesketh, E.L, Bourguet, W, Gruszczyk, J.
Deposit date:2023-09-24
Release date:2024-01-10
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds.
J.Mol.Biol., 436, 2024
5V0L
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BU of 5v0l by Molmil
Crystal structure of the AHR-ARNT heterodimer in complex with the DRE
Descriptor: Aryl hydrocarbon receptor, Aryl hydrocarbon receptor nuclear translocator, CITRIC ACID, ...
Authors:Seok, S.-H, Lee, W, Jiang, L, Bradfield, C.A, Xing, Y.
Deposit date:2017-02-28
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2YPA
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BU of 2ypa by Molmil
Structure of the SCL:E47:LMO2:LDB1 complex bound to DNA
Descriptor: EBOX FORWARD, EBOX REVERSE, LIM DOMAIN-BINDING PROTEIN 1, ...
Authors:El Omari, K, Hoosdally, S.J, Tuladhar, K, Karia, D, Ponsele, E, Platonova, O, Vyas, P, Patient, R, Porcher, C, Mancini, E.J.
Deposit date:2012-10-30
Release date:2013-07-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
Cell Rep., 4, 2013
5SY5
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BU of 5sy5 by Molmil
Crystal Structure of the Heterodimeric NPAS1-ARNT Complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 1
Authors:Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
5SY7
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BU of 5sy7 by Molmil
Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA
Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
Authors:Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
6E3S
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BU of 6e3s by Molmil
Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385
Descriptor: 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15, 2019
6E3T
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BU of 6e3t by Molmil
Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001
Descriptor: (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15, 2019

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