1UKL

Crystal structure of Importin-beta and SREBP-2 complex

Summary for 1UKL

Entry DOI	10.2210/pdb1ukl/pdb
Descriptor	Importin beta-1 subunit, Sterol regulatory element binding protein-2 (2 entities in total)
Functional Keywords	transcription factor, nuclear transport factor, heat repeat, helix-loop-helix leucine zipper, protein transport-dna binding protein complex, protein transport/dna binding protein
Biological source	Mus musculus (house mouse) More
Cellular location	Cytoplasm (By similarity): P70168 Endoplasmic reticulum membrane; Multi-pass membrane protein. Processed sterol regulatory element-binding protein 2: Nucleus: Q12772
Total number of polymer chains	6
Total formula weight	223652.20
Authors	Lee, S.J.,Sekimoto, T.,Yamashita, E.,Nagoshi, E.,Nakagawa, A.,Imamoto, N.,Yoshimura, M.,Sakai, H.,Tsukihara, T.,Yoneda, Y. (deposition date: 2003-08-26, release date: 2003-12-09, Last modification date: 2023-11-15)
Primary citation	Lee, S.J.,Sekimoto, T.,Yamashita, E.,Nagoshi, E.,Nakagawa, A.,Imamoto, N.,Yoshimura, M.,Sakai, H.,Chong, K.T.,Tsukihara, T.,Yoneda, Y. The Structure of Importin-beta Bound to SREBP-2: Nuclear Import of a Transcription Factor Science, 302:1571-1575, 2003 Cited by PubMed: 14645851 DOI: 10.1126/science.1088372 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation