1UKL
Crystal structure of Importin-beta and SREBP-2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005643 | cellular_component | nuclear pore |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006404 | biological_process | RNA import into nucleus |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| A | 0006610 | biological_process | ribosomal protein import into nucleus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0006913 | biological_process | nucleocytoplasmic transport |
| A | 0007079 | biological_process | mitotic chromosome movement towards spindle pole |
| A | 0007080 | biological_process | mitotic metaphase chromosome alignment |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0015031 | biological_process | protein transport |
| A | 0019894 | molecular_function | kinesin binding |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030953 | biological_process | astral microtubule organization |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035332 | biological_process | positive regulation of hippo signaling |
| A | 0040001 | biological_process | establishment of mitotic spindle localization |
| A | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| A | 0061676 | molecular_function | importin-alpha family protein binding |
| A | 0071782 | cellular_component | endoplasmic reticulum tubular network |
| A | 0090307 | biological_process | mitotic spindle assembly |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005643 | cellular_component | nuclear pore |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006404 | biological_process | RNA import into nucleus |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| B | 0006610 | biological_process | ribosomal protein import into nucleus |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0006913 | biological_process | nucleocytoplasmic transport |
| B | 0007079 | biological_process | mitotic chromosome movement towards spindle pole |
| B | 0007080 | biological_process | mitotic metaphase chromosome alignment |
| B | 0008139 | molecular_function | nuclear localization sequence binding |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0015031 | biological_process | protein transport |
| B | 0019894 | molecular_function | kinesin binding |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030953 | biological_process | astral microtubule organization |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035332 | biological_process | positive regulation of hippo signaling |
| B | 0040001 | biological_process | establishment of mitotic spindle localization |
| B | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0051879 | molecular_function | Hsp90 protein binding |
| B | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0061676 | molecular_function | importin-alpha family protein binding |
| B | 0071782 | cellular_component | endoplasmic reticulum tubular network |
| B | 0090307 | biological_process | mitotic spindle assembly |
| C | 0046983 | molecular_function | protein dimerization activity |
| D | 0046983 | molecular_function | protein dimerization activity |
| E | 0046983 | molecular_function | protein dimerization activity |
| F | 0046983 | molecular_function | protein dimerization activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 160 |
| Details | Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 70 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 62 |
| Details | Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 62 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 70 |
| Details | Repeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"HEAT 7","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"HEAT 8","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"HEAT 9","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"10964573","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"HEAT 11","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"HEAT 12","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 96 |
| Details | Repeat: {"description":"HEAT 13","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"HEAT 14","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"HEAT 15","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"HEAT 16","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 96 |
| Details | Repeat: {"description":"HEAT 17","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"HEAT 18","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"HEAT 19","evidences":[{"source":"PubMed","id":"14645851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 352 |
| Details | Region: {"description":"Essential for high affinity interaction with RPL23A","evidences":[{"source":"UniProtKB","id":"Q14974","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 26 |
| Details | Region: {"description":"IAB-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 170 |
| Details | Region: {"description":"Ran-GTP binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"Q14974","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q14974","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q14974","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
