7SSA

Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome

Summary for 7SSA

• Entry DOI: 10.2210/pdb7ssa/pdb
• EMDB information: 25406
• Descriptor: Histone H3.2, Histone H4, Histone H2A.1, ... (7 entities in total)
• Functional Keywords: transcription factor, basic helix-loop-helix, complex, gene regulation
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 12
• Total formula weight: 280357.92

Authors

Eek, P.,Tan, S. (deposition date: 2021-11-10, release date: 2023-04-05, Last modification date: 2023-05-03)

• Primary citation: Donovan, B.T.,Chen, H.,Eek, P.,Meng, Z.,Jipa, C.,Tan, S.,Bai, L.,Poirier, M.G.; Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions.; Mol.Cell, 83:1251-1263.e6, 2023; PubMed: 36996811; DOI: 10.1016/j.molcel.2023.03.006

Experimental method

ELECTRON MICROSCOPY (3.2 Å)