Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

Summary for 4F3L

DescriptorBMAL1b, Circadian locomoter output cycles protein kaput (3 entities in total)
Functional Keywordsbhlh, pas, circadian rhythm proteins, transcription-activator complex, transcription/activator
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight86276.09
Huang, N.,Chelliah, Y.,Shan, Y.,Taylor, C.,Yoo, S.,Partch, C.,Green, C.B.,Zhang, H.,Takahashi, J. (deposition date: 2012-05-09, release date: 2012-06-06, Last modification date: 2018-12-05)
Primary citation
Huang, N.,Chelliah, Y.,Shan, Y.,Taylor, C.A.,Yoo, S.H.,Partch, C.,Green, C.B.,Zhang, H.,Takahashi, J.S.
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337:189-194, 2012
PubMed: 22653727 (PDB entries with the same primary citation)
DOI: 10.1126/science.1222804
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21770 0.4% 14.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report