4F3L
Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000981 | molecular_function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005667 | cellular_component | transcription regulator complex |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0046983 | molecular_function | protein dimerization activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Interaction with E-box DNA => ECO:0000250|UniProtKB:O00327 |
| Chain | Residue | Details |
| B | HIS77 | |
| B | ILE80 | |
| B | GLU81 | |
| B | ARG85 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Important for interaction with CLOCK => ECO:0000250|UniProtKB:O00327 |
| Chain | Residue | Details |
| B | LEU125 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O00327 |
| Chain | Residue | Details |
| B | SER78 | |
| A | SER42 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:19330005 |
| Chain | Residue | Details |
| B | SER90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3) => ECO:0000269|PubMed:18644859 |
| Chain | Residue | Details |
| B | LYS252 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:O00327 |
| Chain | Residue | Details |
| B | LYS259 |
