2YPA

Structure of the SCL:E47:LMO2:LDB1 complex bound to DNA

Summary for 2YPA

Related1HLH 2XJY 2XJZ 2YPB
DescriptorT-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1, TRANSCRIPTION FACTOR E2-ALPHA, RHOMBOTIN-2, ... (7 entities in total)
Functional Keywordsimmune system, hematopoiesis, leukemia
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationNucleus (By similarity) P17542
Nucleus P15923
Nucleus (Potential) P25791
Nucleus (Probable) Q86U70
Total number of polymer chains6
Total molecular weight49615.56
Authors
Primary citation
El Omari, K.,Hoosdally, S.J.,Tuladhar, K.,Karia, D.,Hall-Ponsele, E.,Platonova, O.,Vyas, P.,Patient, R.,Porcher, C.,Mancini, E.J.
Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
Cell Rep., 4:135-, 2013
PubMed: 23831025 (PDB entries with the same primary citation)
DOI: 10.1016/J.CELREP.2013.06.008
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2641 0.3% 1.1% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25