5IRZ
| Structure of TRPV1 determined in lipid nanodisc | Descriptor: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2016-03-15 | Release date: | 2016-05-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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5IRX
| Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc | Descriptor: | (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2016-03-14 | Release date: | 2016-05-25 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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5D68
| Crystal structure of KRIT1 ARD-FERM | Descriptor: | Krev interaction trapped protein 1 | Authors: | Zhang, R, Li, X, Boggon, T.J. | Deposit date: | 2015-08-11 | Release date: | 2015-10-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.908 Å) | Cite: | Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. J.Struct.Biol., 192, 2015
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5CZY
| Crystal structure of LegAS4 | Descriptor: | GLYCEROL, Legionella effector LegAS4, S-ADENOSYLMETHIONINE | Authors: | Son, J, Hwang, K.Y, Lee, W.C. | Deposit date: | 2015-08-01 | Release date: | 2015-09-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4 Biochem.Biophys.Res.Commun., 465, 2015
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5AAR
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3J9P
| Structure of the TRPA1 ion channel determined by electron cryo-microscopy | Descriptor: | Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera | Authors: | Paulsen, C.E, Armache, J.-P, Gao, Y, Cheng, Y, Julius, D. | Deposit date: | 2015-02-14 | Release date: | 2015-04-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.24 Å) | Cite: | Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature, 520, 2015
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3J9J
| Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy | Descriptor: | Transient receptor potential cation channel subfamily V member 1 | Authors: | Wang, R.Y.-R, Barad, B.A, Fraser, J.S, DiMaio, F. | Deposit date: | 2015-02-02 | Release date: | 2015-09-02 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.275 Å) | Cite: | EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy. Nat.Methods, 12, 2015
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4RLV
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4RLY
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4QQI
| Crystal structure of ANKRA2-RFX7 complex | Descriptor: | Ankyrin repeat family A protein 2, DNA-binding protein RFX7, SULFATE ION, ... | Authors: | Xu, C, Tempel, W, Dong, A, Mackenzie, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-06-27 | Release date: | 2014-09-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of ANKRA2-RFX7 complex To Be Published
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4OT9
| crystal structure of the C-terminal domain of p100/NF-kB2 | Descriptor: | Nuclear factor NF-kappa-B p100 subunit, SULFATE ION | Authors: | Tao, Z.H, Huang, D.B, Fusco, A, Gupta, K, Ware, C.F, Duynne, G.V. | Deposit date: | 2014-02-13 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | p100/I kappa B delta sequesters and inhibits NF-kappa B through kappaBsome formation. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OAV
| Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate. | Descriptor: | (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. | Deposit date: | 2014-01-06 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science, 343, 2014
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4OAU
| Complete human RNase L in complex with biological activators. | Descriptor: | 2-5A-dependent ribonuclease, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. | Deposit date: | 2014-01-06 | Release date: | 2014-03-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science, 343, 2014
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3J5P
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3J5Q
| Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy | Descriptor: | Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 | Authors: | Liao, M, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2013-10-28 | Release date: | 2013-12-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | TRPV1 structures in distinct conformations reveal activation mechanisms. Nature, 504, 2013
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3J5R
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4N5Q
| Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Shi, D.J, Ye, S, Cao, X, Wang, K.W, Zhang, R. | Deposit date: | 2013-10-10 | Release date: | 2014-01-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.946 Å) | Cite: | Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function Protein Cell, 4, 2013
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4LG6
| Crystal structure of ANKRA2-CCDC8 complex | Descriptor: | Ankyrin repeat family A protein 2, Coiled-coil domain-containing protein 8, UNKNOWN ATOM OR ION | Authors: | Xu, C, Bian, C, Tempel, W, Mackenzie, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2013-06-27 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8. Structure, 23, 2015
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3W9F
| Crystal structure of the ankyrin repeat domain of chicken TRPV4 in complex with IP3 | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Vanilloid receptor-related osmotically activated channel protein | Authors: | Itoh, Y, Hamada-nakahara, S, Suetsugu, S. | Deposit date: | 2013-04-04 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2 Nat Commun, 5, 2014
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3W9G
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4G8K
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4G8L
| Active state of intact sensor domain of human RNase L with 2-5A bound | Descriptor: | 2-5A-dependent ribonuclease, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE | Authors: | Han, Y, Whitney, G, Donovan, J, Korennykh, A. | Deposit date: | 2012-07-23 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes. Cell Rep, 2, 2012
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4F1P
| Crystal Structure of mutant S554D for ArfGAP and ANK repeat domain of ACAP1 | Descriptor: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, SULFATE ION, ... | Authors: | Sun, F, Pang, X, Zhang, K, Ma, J, Zhou, Q. | Deposit date: | 2012-05-07 | Release date: | 2012-07-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem., 287, 2012
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4DX2
| Crystal structure of the human TRPV4 ankyrin repeat domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Transient receptor potential cation channel subfamily V member 4, ... | Authors: | Inada, H, Gaudet, R. | Deposit date: | 2012-02-27 | Release date: | 2012-07-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51, 2012
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4DX1
| Crystal structure of the human TRPV4 ankyrin repeat domain | Descriptor: | GLYCEROL, PHOSPHATE ION, Transient receptor potential cation channel subfamily V member 4 | Authors: | Inada, H, Gaudet, R. | Deposit date: | 2012-02-27 | Release date: | 2012-07-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51, 2012
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