4OAV

Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.

Summary for 4OAV

• Entry DOI: 10.2210/pdb4oav/pdb
• Related: 4OAU
• Descriptor: PROTEIN (RNase L), RNA (5'-R(P*(PO4)P*(PO4)P*AP*AP*AP*AP*(PO4))-2'), PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (6 entities in total)
• Functional Keywords: hpc1, 2-5a, 2', 5'-oligoadenylate, interferon, dsrna, kinase, rnase, ridd, ire1, rna decay, rnase l protein kinase, pseudokinase, ken-domain containing, regulated rna decay, innate immune response, antiviral response, dsrna response, 5'-linked oligoadenylates; rna, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens; More
• Cellular location: Cytoplasm: Q05823
• Total number of polymer chains: 4
• Total formula weight: 163466.07

Authors

Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A. (deposition date: 2014-01-06, release date: 2014-03-12, Last modification date: 2023-09-20)

• Primary citation: Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A.; Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.; Science, 343:1244-1248, 2014; PubMed: 24578532; DOI: 10.1126/science.1249845

Experimental method

X-RAY DIFFRACTION (2.1 Å)