4OAV
Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, D) | PROTEIN (RNase L) | polymer | 699 | 79416.3 | 2 | UniProt (Q05823) Pfam (PF00023) Pfam (PF00069) Pfam (PF06479) | Homo sapiens | |
| 2 | B, D (A, C) | RNA (5'-R(P*(PO4)P*(PO4)P*AP*AP*AP*AP*(PO4))-2') | polymer | 7 | 1502.7 | 2 | |||
| 3 | E, H (B, D) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 2 | Chemie (ACP) | |||
| 4 | F, G, I, J (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | K (D) | (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate | non-polymer | 520.3 | 1 | Chemie (PUP) | |||
| 6 | L, M, N, O (B, A, D, C) | water | water | 18.0 | 911 | Chemie (HOH) |
Sequence modifications
B, D: 21 - 719 (UniProt: Q05823)
| PDB | External Database | Details |
|---|---|---|
| Asn 672 | His 672 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 161838.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1627.9 | |
| All* | Total formula weight | 163466.1 |
